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犬口腔乳头瘤病中的细胞增殖与凋亡

Cell proliferation and apoptosis in canine oral papillomatosis.

作者信息

Karakurt Emin, Coskun Nuvit, Aydin Ugur, Dag Serpil, Beytut Enver, Ataseven Veysel Soydal, Yilmaz Volkan, Dogan Firat, Nuhoglu Hilmi, Ermutlu Celal Sahin, Yildiz Ayfer

机构信息

Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye.

Department of Virology, Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye.

出版信息

Vet Res Forum. 2024;15(2):75-82. doi: 10.30466/vrf.2023.1996086.3818. Epub 2024 Feb 15.

DOI:10.30466/vrf.2023.1996086.3818
PMID:38465317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10924297/
Abstract

This study was aimed at the evaluation of cell proliferation, level and apoptotic index by immunohistochemical methods in canine oral papillomatosis. The study material comprised of tumor tissue samples taken from six dogs being admitted to the Pathology Department of Faculty of Veterinary Medicine, Kafkas University, Kars, Türkiye. Choice of immunohistochemical staining was avidin-biotin peroxidase method. Cases of canine oral papillomatosis, determined to have been caused by canine papillomavirus-1, were found to have a rather high cell proliferation index. Furthermore, all cases were immunohisto-chemically demonstrated to carry a mutant gene. Despite the mutation of gene, the shift in the / ratio of dogs diagnosed with tumor was in favor of the pro-apoptotic gene. The apoptotic mechanism was determined to occur through both the caspase-dependent and caspase-independent pathways. While the lesions occupied the entire oral cavity in some cases, histopathologically, malignant transformation was not detected in any of the six cases.

摘要

本研究旨在通过免疫组织化学方法评估犬口腔乳头瘤病中的细胞增殖、水平和凋亡指数。研究材料包括从土耳其卡尔斯市卡夫卡大学兽医学院病理科收治的6只犬身上采集的肿瘤组织样本。免疫组织化学染色方法选用抗生物素蛋白-生物素过氧化物酶法。经确定由犬乳头瘤病毒-1引起的犬口腔乳头瘤病病例，其细胞增殖指数相当高。此外，所有病例经免疫组织化学证实均携带一个突变基因。尽管基因发生了突变，但被诊断患有肿瘤的犬的/比值变化有利于促凋亡基因。确定凋亡机制是通过半胱天冬酶依赖性和半胱天冬酶非依赖性途径发生的。虽然在某些病例中病变占据了整个口腔，但在这6例病例中均未检测到组织病理学上的恶性转化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0b/10924297/73cbe66bd954/vrf-15-75-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0b/10924297/3b093d26e42c/vrf-15-75-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0b/10924297/dcb35dd2ac07/vrf-15-75-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0b/10924297/73cbe66bd954/vrf-15-75-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0b/10924297/3b093d26e42c/vrf-15-75-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0b/10924297/5ce10403fc04/vrf-15-75-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0b/10924297/dcb35dd2ac07/vrf-15-75-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0e0b/10924297/73cbe66bd954/vrf-15-75-g004.jpg

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A case series of canine cutaneous inverted papilloma with one case showing evidence of recurrence.
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Front Vet Sci. 2021 Mar 3;8:570982. doi: 10.3389/fvets.2021.570982. eCollection 2021.
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9
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