Ural Federal University, 19 Mira Str., 620002 Ekaterinburg, Russia.
Moscow State University, 1 Leninskie Gory, 119991 Moscow, Russia.
Org Biomol Chem. 2021 May 26;19(20):4429-4459. doi: 10.1039/d1ob00472g.
Polyfluoro(aza)aromatic compounds are of interest in various fields of practical applications, such as medicinal and agrochemistry, materials science and advanced technologies. The C-C coupling reactions are known to be a promising synthetic tool to create challenging fluorinated molecules of diverse architectures. In this review, we have summarized the recent advances in the functionalization of polyfluoro(aza)aromatics via both transition metal-catalyzed and metal-free C-C coupling reactions for the period from 2006 to the beginning of 2021. Also, mechanistic features for chemical transformations of fluoroarene scaffolds and new opportunities for practical applications of the designed fluorinated molecules have been highlighted.
多氟（杂）芳烃化合物在医药和农化、材料科学和先进技术等各个领域的应用中具有重要意义。众所周知，C-C 偶联反应是一种很有前途的合成工具，可用于构建具有不同结构的具有挑战性的氟化分子。在这篇综述中，我们总结了 2006 年至 2021 年初期间通过过渡金属催化和无金属 C-C 偶联反应对多氟（杂）芳烃进行功能化的最新进展。此外，还强调了氟芳烃骨架化学转化的机理特点和设计的氟化分子的实际应用的新机遇。
