Li Lingheng, Li Jinshan
Department of Photography, Tianjin University of Technology, Tianjin 300384, China.
School of Chemistry and Chemical Engineering, Hainan University, Haikou 570228, China.
Molecules. 2024 Feb 2;29(3):697. doi: 10.3390/molecules29030697.
A novel, efficient and environmentally friendly solvent-free and catalyst-free approach for the synthesis of structurally diverse -difluorinated and polyfluoroarylated derivatives with readily available nucleophilic and electrophilic fluorine-containing reaction partners, difluoroenoxysilane and pentafluorobenzaldehyde, is described. This neat protocol is induced by the direct hydrogen-bond interactions between fluorinated and non-fluorinated reactants without the use of heavy metal catalysts or volatile organic solvents and with no need for column chromatographic separation for most cases.
本文描述了一种新颖、高效且环境友好的无溶剂、无催化剂方法，用于合成结构多样的含氟二氟化和多氟芳基化衍生物，反应原料亲核和亲电含氟试剂为易于获得的二氟烯氧基硅烷和五氟苯甲醛。这个简洁的方案是由氟化和非氟化反应物之间的直接氢键相互作用引发的，无需使用重金属催化剂或挥发性有机溶剂，并且在大多数情况下无需柱色谱分离。
