Bain G O, Koch M
Department of Laboratory Medicine, Cross Cancer Institute, Edmonton, Alberta, Canada.
Cancer Detect Prev. 1988;11(3-6):419-22.
The initial histopathologic diagnosis and Rye classification of 172 cases of Hodgkin's disease referred to a regional cancer centre during a period of 8 years was reviewed prospectively by a pathologist in the cancer center who referred 82 cases to a panel made up of pathologists practicing in the region. The proportion of cases with errors in the diagnosis of Hodgkin's disease or Rye classification fell from 47.6% in the first year to 23.1% in the third year and 17.4% in the final year. The performance of the panelists did not vary in any consistent way over the 8-year period. The mean level of agreement among the panelists was 86.7% for the diagnosis of Hodgkin's disease and 63.3% for the Rye classification. A regional program for the ongoing prospective review of all histological diagnoses of Hodgkin's disease can improve the accuracy of initial diagnosis and Rye classification but significant discrepancies persist.
一位癌症中心的病理学家对8年间转诊至某地区癌症中心的172例霍奇金病患者的初始组织病理学诊断和赖氏分类进行了前瞻性回顾。该病理学家将其中82例病例提交给了一个由该地区执业病理学家组成的小组。霍奇金病诊断或赖氏分类错误的病例比例从第一年的47.6%降至第三年的23.1%，并在最后一年降至17.4%。在这8年期间，小组成员的表现没有以任何一致的方式发生变化。小组成员之间对霍奇金病诊断的平均一致率为86.7%，对赖氏分类的平均一致率为63.3%。一项对所有霍奇金病组织学诊断进行持续前瞻性回顾的地区性计划可以提高初始诊断和赖氏分类的准确性，但仍存在显著差异。
