Dorfman R F, Colby T V
Cancer Treat Rep. 1982 Apr;66(4):675-80.
The pathologist's role in the management of patients with Hodgkin's disease may be summarized as follows: (a) to establish a firm diagnosis of Hodgkin's disease: (b) to recognize the value of the Lukes-Butler classification in histologic diagnosis as well as its limitations as a prognostic indicator in patients undergoing modern therapy; (c) to carefully examine and identify all sites of involvement in staging laparotomy material; and (d) to prepare tissues for appropriate histopathologic studies and for new techniques in the investigation of Hodgkin's disease. The pathologist should demand of his or her technician optimal histopathologic sections since technical artifacts frequently compound diagnostic problems. Poor-quality sections clearly constitute one of the major obstacles to the diagnosis and subclassification of Hodgkin's disease and allied disorders.
(a) 确立霍奇金病的确切诊断；(b) 认识到卢克斯-巴特勒分类法在组织学诊断中的价值及其作为接受现代治疗患者预后指标的局限性；(c) 仔细检查并确定分期剖腹术材料中所有受累部位；以及(d) 准备组织用于适当的组织病理学研究和霍奇金病调查的新技术。病理学家应要求其技术人员制作最佳的组织病理学切片，因为技术假象常常使诊断问题复杂化。质量差的切片显然是霍奇金病及相关疾病诊断和亚分类的主要障碍之一。
