Wöckel W
Arch Geschwulstforsch. 1980;50(1):25-35.
According to the Rye classification, four subtypes of Hodgkin's disease are distinguished: lymphocytic predominance, nodular sclerosis, mixed cellularity, and lymphocytic depletion type. In this order of array prognosis is increasingly unfavourable. The importance of the diagnostically relevant Sternberg-Reed cell is discussed. The fact is emphasized that the diagnosis of Hodgkin's disease cannot be made in the absence of diagnostic Sternberg-Reed cells, but the diagnosis must depend on the picture of the section as a whole. The histological feature of the four subtypes is demonstrated. Finally, problems of subclassification, the different data on frequency of the subtypes, the problematic nosological position of Hodgkin's disease, and the obscure histogenetic origin of Sternberg-Reed cells are discussed.
根据赖氏分类法，霍奇金病可分为四种亚型：淋巴细胞为主型、结节硬化型、混合细胞型和淋巴细胞消减型。按此排列顺序，预后越来越差。文中讨论了具有诊断意义的施特恩贝格-里德细胞的重要性。强调了在没有诊断性施特恩贝格-里德细胞的情况下不能做出霍奇金病的诊断，但诊断必须取决于整个切片的表现。展示了四种亚型的组织学特征。最后，讨论了亚型分类问题、各亚型频率的不同数据、霍奇金病有问题的疾病分类位置以及施特恩贝格-里德细胞不明的组织发生起源。
