Alimentómica S.L., 07121 Palma de Mallorca, Balearic Islands, Spain.
Laboratory of Molecular Biology, Nutrition and Biotechnology (Group of Nutrigenomics and Obesity), University of the Balearic Islands (UIB) and Instituto de Investigación Sanitaria Illes Balears (IdISBa), 07122 Palma de Mallorca, Balearic Islands, Spain.
J Agric Food Chem. 2021 May 12;69(18):5281-5296. doi: 10.1021/acs.jafc.1c00737. Epub 2021 Apr 28.
The effects of olive tree (poly)phenols (OPs) are largely dependent upon their bioavailability and metabolization by humans. Absorption, distribution, metabolism, and excretion (ADME) are fundamental for the nutritional efficacy and toxicological impact of foods containing OPs. This review includes studies on the administration of hydroxytyrosol (HT), oleuropein (Ole), or other OPs and foods, products, or mixtures that contain them. Briefly, data from studies indicate that OPs are absorbable by intestinal cells. Both absorption and bioavailability depend upon each compound and/or the matrix in which it is contained. OPs metabolism begins in enterocytes and can also continue in the liver. Metabolic phase I mainly consists of the hydrolysis of Ole, which results in an increase in the HT content. Phase II metabolic reactions involve the conjugation of (poly)phenols mainly with glucuronide and sulfate groups. This review offers a complete perspective of the ADME processes of OPs, which could support the future nutritional and/or toxicological studies in this area.
橄榄油（多）酚（OPs）的作用在很大程度上取决于其在人体内的生物利用度和代谢。吸收、分布、代谢和排泄（ADME）是含 OPs 食品的营养功效和毒理学影响的基础。本综述包括对羟基酪醇（HT）、橄榄苦苷（Ole）或其他 OPs 以及含它们的食品、产品或混合物的管理研究。简要地说，来自[X]项研究的数据表明，OPs 可被肠细胞吸收。吸收和生物利用度都取决于每种化合物和/或其所含的基质。OPs 的代谢始于肠细胞，也可以在肝脏中继续进行。代谢的第一阶段主要包括 Ole 的水解，这导致 HT 含量增加。第二阶段的代谢反应涉及（多）酚的共轭，主要与葡萄糖醛酸和硫酸盐基团。本综述提供了 OPs 的 ADME 过程的全面视角，这可以支持该领域未来的营养和/或毒理学研究。
