铑(III)催化的 2,2'-联吡啶衍生物与亚砜叶立德的可切换 C-H 酰甲基化和环化反应。
Rhodium(iii)-catalyzed switchable C-H acylmethylation and annulation of 2,2'-bipyridine derivatives with sulfoxonium ylides.
机构信息
Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China.
出版信息
Org Biomol Chem. 2021 May 21;19(19):4268-4271. doi: 10.1039/d1ob00590a. Epub 2021 Apr 28.
PMID:33908981
Abstract
A novel protocol for Rh(iii)-catalyzed switchable C-H acylmethylation and annulation of 2,2'-bipyridine derivatives with sulfoxonium ylides is reported. This protocol provides a facile approach to synthesize structurally diverse acylmethylated 2,2'-bipyridine derivatives and acyl pyrido[2,3-a]indolizines with a broad range of functional group tolerance.
摘要
本文报道了一种新型的 Rh(iii)-催化的 2,2'-联吡啶衍生物与亚砜叶立德的可切换 C-H 酰甲基化和环化反应的方案。该方案为合成结构多样的酰甲基化 2,2'-联吡啶衍生物和酰基吡啶并[2,3-a]吲哚嗪提供了一种简便的方法，具有广泛的官能团容忍度。
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