Institute for Systems Analysis and Computer Science "A. Ruberti", National Research Council (IASI-CNR), 00185, Rome, Italy.
Department of Oncology, University of Torino, 10043, Orbassano, Italy.
Angiogenesis. 2021 Aug;24(3):435-450. doi: 10.1007/s10456-021-09779-5. Epub 2021 Apr 28.
The metastatic cancer disease represents the real and urgent clinical need in oncology. Therefore, an understanding of the complex molecular mechanisms sustaining the metastatic cascade is critical to advance cancer therapies. Recent studies highlight how redox signaling influences the behavior of metastatic cancer cells, contributes to their travel in bloodstream from the primary tumor to the distant organs and conditions the progression of the micrometastases or their dormant state. Radical oxygen species not only regulate intracellular processes but participate to paracrine circuits by diffusion to nearby cells, thus assuming unpredicted roles in the communication between metastatic cancer cells, blood circulating cells, and stroma cells at site of colonization. Here, we review recent insights in the role of radical oxygen species in the metastasis formation with a special focus on extravasation at metastatic sites.
转移性癌症疾病代表了肿瘤学中真正且迫切的临床需求。因此，了解维持转移级联的复杂分子机制对于推进癌症治疗至关重要。最近的研究强调了氧化还原信号如何影响转移性癌细胞的行为，促进它们从原发性肿瘤转移到远处器官，并影响微转移或其休眠状态的进展。自由基不仅调节细胞内过程，还通过扩散到附近细胞参与旁分泌回路，从而在转移性癌细胞、循环血液细胞和定植部位基质细胞之间的通信中发挥意想不到的作用。在这里，我们综述了自由基在转移形成中的作用的最新见解，特别关注转移部位的血管外渗。
