Li Lei, Jin Ping, Guan Yueyue, Luo Maochao, Wang Yu, He Bo, Li Bowen, He Kai, Cao Jiangjun, Huang Canhua, Li Jingquan, Shen Zhisen
School of Basic Medical Sciences, State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
State Key Laboratory of Biotherapy and Cancer Center, West China School of Basic Medical Sciences & Forensic Medicine, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
Pharmaceuticals (Basel). 2022 Dec 12;15(12):1540. doi: 10.3390/ph15121540.
Polyphenol, one of the major components that exert the therapeutic effect of Chinese herbal medicine (CHM), comprises several categories, including flavonoids, phenolic acids, lignans and stilbenes, and has long been studied in oncology due to its significant efficacy against cancers in vitro and in vivo. Recent evidence has linked this antitumor activity to the role of polyphenols in the modulation of redox homeostasis (e.g., pro/antioxidative effect) in cancer cells. Dysregulation of redox homeostasis could lead to the overproduction of reactive oxygen species (ROS), resulting in oxidative stress, which is essential for many aspects of tumors, such as tumorigenesis, progression, and drug resistance. Thus, investigating the ROS-mediated anticancer properties of polyphenols is beneficial for the discovery and development of novel pharmacologic agents. In this review, we summarized these extensively studied polyphenols and discussed the regulatory mechanisms related to the modulation of redox homeostasis that are involved in their antitumor property. In addition, we discussed novel technologies and strategies that could promote the development of CHM-derived polyphenols to improve their versatile anticancer properties, including the development of novel delivery systems, chemical modification, and combination with other agents.
多酚是发挥中药治疗作用的主要成分之一，包括黄酮类、酚酸类、木脂素类和芪类等几大类。由于其在体外和体内对癌症具有显著疗效，长期以来一直是肿瘤学领域的研究热点。最近的证据表明，这种抗肿瘤活性与多酚在调节癌细胞氧化还原稳态（如促氧化/抗氧化作用）中的作用有关。氧化还原稳态失调会导致活性氧（ROS）过度产生，从而引起氧化应激，而氧化应激在肿瘤发生、发展和耐药等许多方面都起着至关重要的作用。因此，研究多酚通过ROS介导的抗癌特性有助于发现和开发新型药物。在这篇综述中，我们总结了这些经过广泛研究的多酚，并讨论了与其抗肿瘤特性相关的氧化还原稳态调节机制。此外，我们还讨论了能够促进源自中药的多酚发展以改善其多种抗癌特性的新技术和策略，包括新型给药系统的开发、化学修饰以及与其他药物联合使用。
