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听觉皮层回路的发育。

Development of Auditory Cortex Circuits.

机构信息

Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, 720 Rutland Avenue/ Miller 379, Baltimore, MD, 21205, USA.

出版信息

J Assoc Res Otolaryngol. 2021 Jun;22(3):237-259. doi: 10.1007/s10162-021-00794-3. Epub 2021 Apr 28.

Abstract

The ability to process and perceive sensory stimuli is an essential function for animals. Among the sensory modalities, audition is crucial for communication, pleasure, care for the young, and perceiving threats. The auditory cortex (ACtx) is a key sound processing region that combines ascending signals from the auditory periphery and inputs from other sensory and non-sensory regions. The development of ACtx is a protracted process starting prenatally and requires the complex interplay of molecular programs, spontaneous activity, and sensory experience. Here, we review the development of thalamic and cortical auditory circuits during pre- and early post-natal periods.

摘要

处理和感知感觉刺激的能力是动物的基本功能。在感觉模态中,听觉对于交流、娱乐、照顾幼崽和感知威胁至关重要。听觉皮层(ACtx)是一个关键的声音处理区域,它结合了来自听觉外围的上行信号和来自其他感觉和非感觉区域的输入。ACtx 的发育是一个从产前开始并需要分子程序、自发活动和感觉体验的复杂相互作用的漫长过程。在这里,我们回顾了产前和产后早期听觉丘脑和皮质回路的发育。

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