Danso Mavis, Anto Francis
School of Public Health, University of Ghana, Legon, Accra, Ghana.
Food and Drugs Authority, Accra, Ghana.
Drugs Real World Outcomes. 2021 Sep;8(3):337-347. doi: 10.1007/s40801-021-00247-6. Epub 2021 Apr 28.
There is increasing public health concern regarding the addiction and dependence potential of tramadol.
This study sought to determine factors associated with tramadol abuse among commercial drivers and assistants in the Accra Metropolitan Area of Ghana.
The study employed a mixed-method quantitative and qualitative approach. It involved a cross-sectional survey and focus group discussions with commercial drivers and assistants at selected transport terminals in Accra. Data on abuse, reasons for abuse, sources of supply, and factors associated with abuse were collected from the respondents and analyzed using STATA and Nvivo, as appropriate.
Of the 458 study participants, 114 (24.9%) indicated that they abused tramadol. The mean (± standard deviation) age of those who abused tramadol (25.14 ± 5.87 years) was significantly lower than that of nonabusers (28.23 ± 9.6 years), t(456) = -3.60; p = 0.001. The level of risk of dependence on tramadol among the abusers was high, as 49.1% (56/114) of abusers were estimated to have a composite risk score of ≥ 27. Various socioenvironmental factors, including tension or fighting among family members (adjusted odds ratio [AOR] 7.73; 95% confidence interval [CI] 3.33-17.98; p < 0.001), abuse of drugs by a family member (AOR 2.27; 95% CI 1.26-4.11; p = 0.007), and having a friend who abused drugs (AOR 2.17; 95% CI 1.22-3.89; p = 0.009) were associated with tramadol abuse. Reasons given for using tramadol included pain relief and sexual enhancement.
The level of tramadol abuse and dependence was high. This calls for interventional programs, including health education, as dependency on tramadol has dire consequences on productivity.
曲马多的成瘾和依赖潜力引发了越来越多的公共卫生关注。
本研究旨在确定加纳阿克拉大都会地区商业司机和助手滥用曲马多的相关因素。
本研究采用定量与定性相结合的混合方法。研究包括一项横断面调查以及与阿克拉选定交通终点站的商业司机和助手进行焦点小组讨论。从受访者处收集关于滥用情况、滥用原因、供应来源以及与滥用相关因素的数据,并酌情使用STATA和Nvivo进行分析。
在458名研究参与者中,114人(24.9%)表示他们滥用曲马多。滥用曲马多者的平均(±标准差)年龄(25.14±5.87岁)显著低于未滥用者(28.23±9.6岁),t(456)= -3.60;p = 0.001。滥用者对曲马多的依赖风险水平较高,估计49.1%(56/114)的滥用者综合风险评分≥27。各种社会环境因素,包括家庭成员间的紧张关系或争吵(调整后的优势比[AOR]7.73;95%置信区间[CI]3.33 - 17.98;p < 0.001)、家庭成员滥用药物(AOR 2.27;95%CI 1.26 - 4.11;p = 0.007)以及有滥用药物的朋友(AOR 2.17;95%CI 1.22 - 3.89;p = 0.009)与曲马多滥用有关。使用曲马多的原因包括缓解疼痛和增强性功能。
曲马多的滥用和依赖程度较高。这需要开展包括健康教育在内的干预项目,因为对曲马多的依赖会对生产力产生严重后果。