埃塞俄比亚哈瓦萨市哈瓦萨大学学生中曲马多滥用情况及其相关因素

The prevalence of Tramadol abuse and associated factors among Hawassa University students, Hawassa, Ethiopia.

作者信息

Legasse Adanech Shifarew, Tamiru Wudinesh, Mohammed Fatiya, Ataro Getu

机构信息

Department of Anesthesia, Faculty of Medicine, College of medicine and health science, Hawassa University, Hawassa, Sidama, Ethiopia.

出版信息

PLoS One. 2025 Mar 10;20(3):e0318634. doi: 10.1371/journal.pone.0318634. eCollection 2025.

DOI:10.1371/journal.pone.0318634

PMID:40063646

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11892866/

Abstract

INTRODUCTION

Tramadol abuse is a current public health concern in Ethiopia. Drug abuse including that of tramadol is a significant public health issue that causes health, economic, and social problems to individual drug users, their families, the community, and the entire nation. Therefore this study delivers information regarding current tramadol abuse among students of an Ethiopian University.

OBJECTIVE

The aim of this study is to assess the prevalence of tramadol abuse and associated factors among Hawassa university students, February to June 2023.

METHODS AND MATERIALS

A cross-sectional study was performed among 402 randomly selected Hawassa university students. Data was collected from participant through self-administered researcher made questionnaire using kobo toolbox software applications. Data from kobo toolbox were directly exported to and analyzed by using SPSS version 26 software. Binary logistic regression was applied to identify the factors associated with tramadol abuse. In the final model, Adjusted Odds Ratio, and 95% CI was used to measure the strength of association and P-value less than 0.05 considered statistically significant.

RESULT

A total of 402 students were enrolled in this study of which 46 students (11.4%) [95% CI 8.5-14.7] had history of tramadol abuse once in their lifetime with 23.9% of them were active tramadol abuser with some dependence behaviors. The result of multivariate analysis shows that having a friend who use drugs [AOR = 1.691, 95% CI (0.718-3.980), p = 0.041], knowing about tramadol [AOR = 13.766, 95%CI (3.003-63.113), p = 0.001] and having the history of taking tramadol with physicians prescription in their life time [AOR = 7.960, 95%CI (3.603-17.587), P < 0.001] were the significant predictors of tramadol abuse.

CONCLUSION

The life time prevalence of tramadol abuse among university students is high and it demands attention of government and the general public.

摘要

引言

曲马多滥用是埃塞俄比亚当前的一个公共卫生问题。包括曲马多在内的药物滥用是一个重大的公共卫生问题，会给个体吸毒者、他们的家庭、社区乃至整个国家带来健康、经济和社会问题。因此，本研究提供了有关埃塞俄比亚一所大学学生中当前曲马多滥用情况的信息。

目的

本研究的目的是评估2023年2月至6月哈瓦萨大学学生中曲马多滥用的患病率及相关因素。

方法和材料

对402名随机抽取的哈瓦萨大学学生进行了一项横断面研究。通过使用kobo工具箱软件应用程序，由研究人员自行设计的问卷从参与者那里收集数据。来自kobo工具箱的数据直接导出并使用SPSS 26版软件进行分析。应用二元逻辑回归来确定与曲马多滥用相关的因素。在最终模型中，调整后的优势比和95%置信区间用于衡量关联强度，P值小于0.05被认为具有统计学意义。

结果

本研究共纳入402名学生，其中46名学生（11.4%）[95%置信区间8.5 - 14.7]有过曲马多滥用史，其中23.9%是有一些依赖行为的活跃曲马多滥用者。多变量分析结果显示，有吸毒的朋友[AOR = 1.691，95%置信区间(0.718 - 3.980)，p = 0.041]、了解曲马多[AOR = 13.766，95%置信区间(3.003 - 63.113)，p = 0.001]以及一生中曾有过按医生处方服用曲马多的经历[AOR = 7.960，95%置信区间(3.603 - 17.587)，P < 0.001]是曲马多滥用的显著预测因素。