Faculty of Biological Sciences, Centre for Plant Science, University of Leeds, Leeds, LS2 9JT, UK.
New Phytol. 2021 Aug;231(3):963-973. doi: 10.1111/nph.17428. Epub 2021 May 30.
Transcriptional corepressors play important roles in establishing the appropriate levels of gene expression during growth and development. The TOPLESS (TPL) family of corepressors are critical for all plant life. TPLs are involved in numerous developmental processes and in the response to extrinsic challenges. As such these proteins have been the focus of intense study since Long and colleagues first described the TPL corepressor in 2006. In this review we will explore the evolutionary history of these essential plant-specific proteins, their mechanism of action based on recent structural analyses, and the myriad of pathways in which they function. We speculate how relatively minor changes in the peptide sequence of transcriptional regulators allowed them to recruit TPL into new processes, driving innovation and resulting in TPL becoming vital for plant development.
转录核心抑制因子在生长和发育过程中对基因表达水平的调节起着重要作用。TOPLESS（TPL）家族的核心抑制因子对于所有植物的生命都是至关重要的。TPL 参与了许多发育过程以及对外界挑战的反应。因此，自从 Long 及其同事在 2006 年首次描述 TPL 核心抑制因子以来，这些蛋白质一直是研究的焦点。在这篇综述中，我们将探讨这些必需的植物特异性蛋白的进化历史、基于最近结构分析的作用机制，以及它们在其中发挥作用的众多途径。我们推测转录调控因子的肽序列的微小变化如何使它们能够将 TPL 招募到新的过程中，推动创新，并使 TPL 对植物发育变得至关重要。
