HitGen Inc., Building 6, No. 8 Huigu First East Road, Tianfu International Bio-Town, Shuangliu District, Chengdu 610200, Sichuan, P. R. China.
Org Lett. 2021 May 7;23(9):3486-3490. doi: 10.1021/acs.orglett.1c00924. Epub 2021 Apr 28.
A highly efficient approach to C(sp)-C(sp) bond construction via on-DNA photoredox catalysis between on-DNA alkenes and -aryl tertiary amines was developed. The methodology demonstrated 55%-95% conversions without obvious DNA damage, as seen by qPCR tests. Furthermore, various functional groups, such as carboxylic acids, aldehydes, and aryl halides, that can be used to create library diversities were shown to be tolerant of the C-H activation conditions.
通过 DNA 上烯烃与芳基叔胺之间的 DNA 光氧化还原催化，开发了一种高效构建 C(sp)-C(sp)键的方法。该方法在 qPCR 测试中显示出 55%-95%的转化率，且没有明显的 DNA 损伤。此外，各种官能团，如羧酸、醛和芳基卤化物，可用于创建库多样性，它们对 C-H 活化条件具有耐受性。
