Hematology Service, Facultad de Medicina y Hospital Universitario "Dr José Eleuterio González," Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, Mexico.
Child Health Evaluation Services, Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada.
JCO Glob Oncol. 2021 Apr;7:622-631. doi: 10.1200/GO.20.00600.
Establishing research capacity in low- and middle-income countries (LMICs) is key for improving the outcomes of patients with hematologic diseases globally. Few studies have analyzed the contributions of LMICs to global hematology. The American Society of Hematology Meeting (ASH) is the largest international academic event where peer-reviewed contributions in our field are presented.
In this cross-sectional analysis, all abstracts accepted to ASH 2018 selected for a poster or oral presentation were reviewed. Those that had a contributing author from an LMIC were identified. The proportion of LMIC abstracts across categories was analyzed. Country of origin, high-income country participation, the presence of a conflict of interest (COI), and sponsorship were determined.
From 4,871 abstracts reviewed, 506 had a contributing author from an LMIC (10.4%), with 277 (54.7%) contributions in partnership with a high-income country. LMIC-independent contributions corresponded to 19 of 1,026 oral abstracts (1.9%) and 209 of 3,845 posters (5.4%). Most abstracts from LMICs were clinical (n = 311; 61.5%) and multicentric in nature (n = 353; 69.8%). COI statements with the pharmaceutical industry were common (n = 214; 42.3%). Collaboration between LMICs was infrequent (n = 33; 6.5%). Upper-middle-income countries had 466 participations (81.5%), in comparison with 96 (16.8%) in low-middle-income and 10 (1.7%) in low-income countries.
LMICs were responsible for a small fraction of abstracts at ASH18; low-income countries were practically absent. Almost half of accepted works represented a form of international collaboration, with clinical, multicenter studies predominating and COI disclosures a frequent and unexpected feature, reflecting the instrumental nature of LMIC participation and a lack of independent, robust, locally developed hematology research.
在中低收入国家（LMICs）建立研究能力对于改善全球血液病患者的治疗效果至关重要。很少有研究分析 LMICs 对全球血液学的贡献。美国血液学会会议（ASH）是最大的国际学术活动，会上展示了我们领域的同行评审研究成果。
在这项横断面分析中，对所有被 ASH2018 接受的用于海报或口头报告的摘要进行了回顾。确定了来自 LMIC 的贡献作者的摘要。分析了各个类别中的 LMIC 摘要的比例。确定了来源国、高收入国家的参与情况、利益冲突（COI）的存在以及赞助情况。
在审查的 4871 篇摘要中，有 506 篇摘要的贡献作者来自 LMIC（占 10.4%），其中 277 篇（占 54.7%）是与高收入国家合作的。与高收入国家合作的独立贡献对应于 19 篇口头摘要（占 1.9%）和 3845 篇海报中的 209 篇（占 5.4%）。来自 LMIC 的大多数摘要都是临床研究（n=311；占 61.5%）和多中心性质的（n=353；占 69.8%）。与制药行业的利益冲突声明很常见（n=214；占 42.3%）。LMIC 之间的合作很少见（n=33；占 6.5%）。中上收入国家有 466 项参与（占 81.5%），而低收入和中等收入国家分别有 96 项（占 16.8%）和 10 项（占 1.7%）。
LMIC 在 ASH18 上的摘要数量很少；低收入国家几乎没有。几乎一半的被接受的工作代表了一种国际合作形式，以临床、多中心研究为主，利益冲突披露是一个常见且意外的特征，这反映了 LMIC 参与的工具性质以及缺乏独立、稳健、本土化的血液学研究。
