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LOXL1 基因多态性与剥脱综合征/剥脱性青光眼风险相关：一项更新的荟萃分析。

LOXL1 gene polymorphisms are associated with exfoliation syndrome/exfoliation glaucoma risk: An updated meta-analysis.

机构信息

Department of Endocrinology, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.

Department of Pulmonary and Critical Care Medicine, Clinical Medical College and The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China.

出版信息

PLoS One. 2021 Apr 28;16(4):e0250772. doi: 10.1371/journal.pone.0250772. eCollection 2021.

DOI:10.1371/journal.pone.0250772
PMID:33909695
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8081202/
Abstract

BACKGROUND

Single nucleotide polymorphisms (SNPs) in the gene encoding LOXL1 are risk factors for exfoliation syndrome and exfoliation glaucoma. This meta-analysis comprehensively investigated the association between LOXL1 gene polymorphisms (rs1048661, rs3825942, and rs2165241) and the risk of exfoliation syndrome/exfoliation glaucoma (XFS)/(XFG).

METHODS

All eligible case-control studies, published before August 17, 2020, were searched on Medline (Ovid), PubMed, CNKI, EMBASE, and Wanfang databases.

RESULTS

In total, 5022 cases and 8962 controls were included in this meta-analysis. Significant associations between LOXL1 gene polymorphisms and XFS/XFG risk was observed in the disease types-based subgroups. In addition, in the subgroup analysis of ethnicity, positive associations between LOXL1 gene polymorphisms (rs1048661, rs3825942, and rs2165241) and XFS/XFG risk were found in Caucasians. Furthermore, rs1048661 and rs3825942 polymorphisms were related to XFS/ XFG risk in Asians; however, no significant association was observed between the LOXL1 gene rs2165241 polymorphism and XFS/XFG risk in Asians. In addition, rs1048661 and rs3825942 correlated with XFS/XFG susceptibility in Africans.

CONCLUSIONS

Our results implicate LOXL1 gene polymorphisms as XFS/XFG risk factors, especially in Caucasians.

摘要

背景

编码 LOXL1 基因的单核苷酸多态性（SNPs）是剥脱综合征和剥脱性青光眼的危险因素。本荟萃分析全面研究了 LOXL1 基因多态性（rs1048661、rs3825942 和 rs2165241）与剥脱综合征/剥脱性青光眼（XFS/XFG）风险之间的关系。

方法

检索 Medline（Ovid）、PubMed、CNKI、EMBASE 和万方数据库，获取截至 2020 年 8 月 17 日前发表的所有合格病例对照研究。

结果

共有 5022 例病例和 8962 例对照纳入本荟萃分析。在基于疾病类型的亚组中，观察到 LOXL1 基因多态性与 XFS/XFG 风险之间存在显著关联。此外，在种族亚组分析中，在白种人中发现 LOXL1 基因多态性（rs1048661、rs3825942 和 rs2165241）与 XFS/XFG 风险之间存在阳性关联。此外，rs1048661 和 rs3825942 多态性与亚洲人群的 XFS/XFG 风险相关；然而，在亚洲人群中，未观察到 LOXL1 基因 rs2165241 多态性与 XFS/XFG 风险之间存在显著关联。此外，rs1048661 和 rs3825942 与非洲人群的 XFS/XFG 易感性相关。

结论

我们的研究结果提示 LOXL1 基因多态性是 XFS/XFG 的危险因素，尤其是在白种人群中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/d67a60a4cee2/pone.0250772.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/c20b84cc6e74/pone.0250772.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/f27463fbe2d8/pone.0250772.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/abd83d978bc5/pone.0250772.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/87a4f60b13ba/pone.0250772.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/8eb979d978fa/pone.0250772.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/46006cce1133/pone.0250772.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/e4f1c587551c/pone.0250772.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/d67a60a4cee2/pone.0250772.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/c20b84cc6e74/pone.0250772.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/f27463fbe2d8/pone.0250772.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/abd83d978bc5/pone.0250772.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/87a4f60b13ba/pone.0250772.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/8eb979d978fa/pone.0250772.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/46006cce1133/pone.0250772.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/e4f1c587551c/pone.0250772.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a6d/8081202/d67a60a4cee2/pone.0250772.g008.jpg

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