In vitro interactions of amikacin and beta-lactam antibiotics against amikacin-resistant gram-negative bacilli.
作者信息
Alvarez S, Jones M, Holtsclaw-Berk S, Berk S L
机构信息
Infectious Disease Section, VA Medical Center, Johnson City, Tenn.
出版信息
Chemotherapy. 1988;34(2):107-12. doi: 10.1159/000238556.
PMID:3391050
Abstract
We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time-kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combination by the checkerboard technique, while amikacin-cefoperazone was the most active combination by the time-killing curve technique against Pseudomonas aeruginosa. Discrepancies were found between the results of the two methods used.
摘要
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