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In vitro interactions of amikacin and beta-lactam antibiotics against amikacin-resistant gram-negative bacilli.

作者信息

Alvarez S, Jones M, Holtsclaw-Berk S, Berk S L

机构信息

Infectious Disease Section, VA Medical Center, Johnson City, Tenn.

出版信息

Chemotherapy. 1988;34(2):107-12. doi: 10.1159/000238556.

DOI:10.1159/000238556
PMID:3391050
Abstract

We tested 42 strains of amikacin-resistant gram-negative bacilli with amikacin in combination with six beta-lactam antibiotics using the checkerboard and time-kill curve techniques. Synergism was demonstrated with time-killing curve in 43-68% of the strains tested. Ceftazidime plus amikacin was the most active combination by the checkerboard technique, while amikacin-cefoperazone was the most active combination by the time-killing curve technique against Pseudomonas aeruginosa. Discrepancies were found between the results of the two methods used.

摘要

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引用本文的文献

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In vitro activities of cefepime alone and with amikacin against aminoglycoside-resistant gram-negative bacteria.头孢吡肟单独及与阿米卡星联合对氨基糖苷类耐药革兰阴性菌的体外活性。
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