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阿米卡星与六种β-内酰胺类抗生素对多重耐药肠杆菌科细菌的早期协同相互作用。

Early synergistic interactions between amikacin and six beta-lactam antibiotics against multiply resistant members of the family Enterobacteriaceae.

作者信息

Glew R H, Pavuk R A

出版信息

Antimicrob Agents Chemother. 1984 Sep;26(3):378-81. doi: 10.1128/AAC.26.3.378.

DOI:10.1128/AAC.26.3.378
PMID:6508266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176174/
Abstract

An in vitro comparison of the early synergistic interaction between amikacin and each of six beta-lactam antibiotics was made by using time-kill curves against 48 multiply resistant members of the family Enterobacteriaceae. Overall, these six combinations demonstrated early synergism (greater than or equal to 2 logs of increased kill after 7 h of incubation) against the 48 strains on 74% (range, 67 to 85%) of occasions; cefotaxime-amikacin and piperacillin-amikacin were the most efficacious combinations. Antagonism was not observed with any of the combinations against any of the 48 Enterobacteriaceae strains tested.

摘要

通过针对48株多重耐药肠杆菌科细菌绘制时间杀菌曲线，对阿米卡星与六种β-内酰胺类抗生素各自之间的早期协同相互作用进行了体外比较。总体而言，这六种联合用药方案在74%（范围为67%至85%）的情况下，对48株菌株表现出早期协同作用（孵育7小时后杀灭增加大于或等于2个对数）；头孢噻肟-阿米卡星和哌拉西林-阿米卡星是最有效的联合用药方案。在所测试的48株肠杆菌科菌株中，未观察到任何一种联合用药方案存在拮抗作用。

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本文引用的文献

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Antimicrob Agents Chemother. 1982 Dec;22(6):985-9. doi: 10.1128/AAC.22.6.985.
2
Antibiotic combinations.抗生素联合使用
Med Clin North Am. 1982 Jan;66(1):17-24. doi: 10.1016/s0025-7125(16)31438-9.
3
Comparative susceptibilities of clinical isolates of Serratia marcescens to newer cephalosporins, alone and in combination with various aminoglycosides.粘质沙雷氏菌临床分离株对新型头孢菌素单独及与各种氨基糖苷类联合使用时的敏感性比较。
Antimicrob Agents Chemother. 1980 Nov;18(5):651-5. doi: 10.1128/AAC.18.5.651.
4
Activities of various beta-lactams and aminoglycosides, alone and in combination, against isolates of Pseudomonas aeruginosa from patients with cystic fibrosis.多种β-内酰胺类药物和氨基糖苷类药物单独及联合使用时，对囊性纤维化患者分离出的铜绿假单胞菌菌株的活性。
Antimicrob Agents Chemother. 1982 Jun;21(6):939-43. doi: 10.1128/AAC.21.6.939.
5
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