阿米卡星与六种β-内酰胺类抗生素对多重耐药肠杆菌科细菌的早期协同相互作用。
Early synergistic interactions between amikacin and six beta-lactam antibiotics against multiply resistant members of the family Enterobacteriaceae.
作者信息
Glew R H, Pavuk R A
出版信息
Antimicrob Agents Chemother. 1984 Sep;26(3):378-81. doi: 10.1128/AAC.26.3.378.
Abstract
An in vitro comparison of the early synergistic interaction between amikacin and each of six beta-lactam antibiotics was made by using time-kill curves against 48 multiply resistant members of the family Enterobacteriaceae. Overall, these six combinations demonstrated early synergism (greater than or equal to 2 logs of increased kill after 7 h of incubation) against the 48 strains on 74% (range, 67 to 85%) of occasions; cefotaxime-amikacin and piperacillin-amikacin were the most efficacious combinations. Antagonism was not observed with any of the combinations against any of the 48 Enterobacteriaceae strains tested.
摘要
通过针对48株多重耐药肠杆菌科细菌绘制时间杀菌曲线，对阿米卡星与六种β-内酰胺类抗生素各自之间的早期协同相互作用进行了体外比较。总体而言，这六种联合用药方案在74%（范围为67%至85%）的情况下，对48株菌株表现出早期协同作用（孵育7小时后杀灭增加大于或等于2个对数）；头孢噻肟-阿米卡星和哌拉西林-阿米卡星是最有效的联合用药方案。在所测试的48株肠杆菌科菌株中，未观察到任何一种联合用药方案存在拮抗作用。
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