Department of Endocrinology, Beijing Shijitan Hospital, Capital Medical University, No.10 Tieyi Road, Haidian District, Beijing, 100038, China.
Department of Thyroid and Neck Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020, China.
J Otolaryngol Head Neck Surg. 2021 Apr 28;50(1):30. doi: 10.1186/s40463-021-00509-x.
Dysregulated lncRNA score and PVT1 expression may be involved in cancer. However, relationships of lncRNAs with hyperparathyroidism and parathyroid cancer (PC) diagnosis remain mysterious.
Using quantitative real-time polymerase chain reaction (RT-qPCR), expression profile of PVT1 was evaluated in 57 patients with primary hyperparathyroidism, including 11 with parathyroid cancer (PC) and 46 with parathyroid adenoma (PA).
Higher levels of lncRNA score and PVT1 expression were associated with increased serum calcium level after water ingestion and PC risk (P < 0.05). Accordingly, lncRNA score and PVT1 expression were increased with varying degrees of hypercalcemia in PC. A higher level of lncRNA score (but not PVT1) was an independent risk factor of PC, with an AUC up to 0.872 (95% CI: 0.756-0.945, P < 0.001). Moreover, lncRNA score was more valuable (with AUC 0.974, sensitivity of 85.71% and specificity of 100%, respectively) than intact parathyroid hormone (iPTH) in predicting risk of PC among patients with hypercalcemia (especially based on greater AUC, P = 0.010).
Increased lncRNA score is correlated with an elevated level of serum calcium, which may serve as a potential biomarker for PC diagnosis, especially with hypercalcemia.
失调的长链非编码 RNA 评分和 PVT1 表达可能与癌症有关。然而，lncRNAs 与甲状旁腺功能亢进和甲状旁腺癌（PC）诊断之间的关系仍然神秘。
使用实时定量聚合酶链反应（RT-qPCR），评估了 57 例原发性甲状旁腺功能亢进患者中 PVT1 的表达谱，包括 11 例甲状旁腺癌（PC）和 46 例甲状旁腺瘤（PA）。
lncRNA 评分和 PVT1 表达水平升高与饮水后血清钙水平升高和 PC 风险增加相关（P<0.05）。因此，lncRNA 评分和 PVT1 表达随着 PC 中不同程度的高钙血症而升高。较高的 lncRNA 评分水平（而非 PVT1）是 PC 的独立危险因素，AUC 高达 0.872（95%CI：0.756-0.945，P<0.001）。此外，lncRNA 评分（AUC 为 0.974，灵敏度为 85.71%，特异性为 100%）比完整甲状旁腺激素（iPTH）更能预测高钙血症患者 PC 的风险（尤其是基于更大的 AUC，P=0.010）。
lncRNA 评分的增加与血清钙水平升高相关，可能作为 PC 诊断的潜在生物标志物，尤其是在高钙血症时。
