Lee JaeYong, Lee Jongin, Ahn Joonho, Lee Dong-Wook, Kim Hyoung-Ryoul, Kang Mo-Yeol
Department of Occupational and Environmental Medicine, Seoul St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Republic of Korea.
Department of Preventive Medicine, Occupational & Environmental Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Occup Environ Med. 2022 Apr;79(4):277-286. doi: 10.1136/oemed-2020-107253. Epub 2021 Apr 28.
There has been no research on sedentary behaviour in the occupational domain that occupies a large portion of the daily life.
We conducted a meta-analysis to investigate the association between sedentary work and colorectal cancer. We searched PubMed, Embase and Cochrane databases up to 12 August 2020 for peer-reviewed journal articles that assessed the association between sedentary work and colon or rectal cancer. Pooled estimates of ORs were obtained using random effects models. Statistical tests for publication bias, heterogeneity and sensitivity analysis were applied.
Of the 5 381 studies initially identified, 23 studies with 64 reports were eligible for inclusion. Sedentary work significantly increased the risk of colon cancer (pooled OR=1.21, 95% CI 1.11 to 1.31, p value ≤0.0001) and rectal cancer (pooled OR=1.08, 95% CI 1.00 to 1.16, p value=0.0395). The adjustment for leisure time physical activity attenuated the association and made the risk estimates non-significant for sedentary behaviour, but the association was independent of sex, control of body mass index and assessment of sedentary behaviour.
We found evidence of association between sedentary work and the risk of colon or rectal cancer. Limiting excessive sedentary work could be an important means of preventing colon and rectal cancer.
在占据日常生活很大一部分的职业领域中，尚未有关于久坐行为的研究。
我们进行了一项荟萃分析，以调查久坐工作与结直肠癌之间的关联。我们检索了截至2020年8月12日的PubMed、Embase和Cochrane数据库，查找评估久坐工作与结肠癌或直肠癌之间关联的同行评审期刊文章。使用随机效应模型获得合并的比值比（OR）估计值。应用了发表偏倚、异质性和敏感性分析的统计检验。
在最初识别的5381项研究中，有23项研究（64份报告）符合纳入标准。久坐工作显著增加了患结肠癌的风险（合并OR = 1.21，95%可信区间1.11至1.31，p值≤0.0001）和直肠癌的风险（合并OR = 1.08，95%可信区间1.00至1.16，p值 = 0.0395）。对休闲时间体力活动的调整减弱了这种关联，并使久坐行为的风险估计无统计学意义，但这种关联独立于性别、体重指数的控制和久坐行为的评估。
我们发现了久坐工作与结肠癌或直肠癌风险之间存在关联的证据。限制过度的久坐工作可能是预防结肠癌和直肠癌的重要手段。
