Kofi-Tsekpo W M, Karekezi C W
Kenya Medical Research Institute, Traditional Medicines and Drugs Research Centre, Nairobi.
Drugs Exp Clin Res. 1988;14(1):31-7.
Although amoscanate has been established as a potent antischistosomal drug, its detectability and measurability in biological fluids has been in doubt. Experiments have been carried out to show that these measurements can be made. High pressure liquid chromatographic (HPLC) and thin layer chromatographic (TLC) analyses have been performed on plasma samples incubated with plasma at 37 degrees C. Specific chemical detection methods of functional groups in the molecule were used to establish the identity of the drug on TLC plates, and the results were found to correlate with the HPLC analyses.
尽管硝硫氰胺已被确认为一种有效的抗血吸虫药物，但其在生物体液中的可检测性和可测量性一直受到质疑。已开展实验以表明这些测量是可行的。对在37摄氏度下与血浆一起孵育的血浆样本进行了高压液相色谱（HPLC）和薄层色谱（TLC）分析。使用分子中官能团的特定化学检测方法在TLC板上确定药物的身份，结果发现与HPLC分析相关。
