Cho Young Min, Jung Kyung Eun, Koo Dae Won, Lee Joong Sun
Department of Dermatology, School of Medicine, Eulji University, Daejeon, Korea.
Ann Dermatol. 2018 Oct;30(5):550-555. doi: 10.5021/ad.2018.30.5.550. Epub 2018 Aug 28.
Confluent and reticulated papillomatosis (CRP) is an uncommon dermatosis characterized by hyperpigmented scaly macules or papillomatous papules coalescing into confluent patches or plaques centrally with a reticular pattern peripherally. Few studies regarding this have been reported in the literature.
The purpose of this study was to investigate the clinical and histologic characteristics of CRP in Korean patients according to anatomic site and age.
We retrospectively reviewed the medical records, clinical photographs, and 40 histopathologic slides of 29 patients diagnosed with CRP.
Sixteen adults and 13 adolescents were included. The predominantly involved anatomic sites were the trunk (89.7%) and axillae (27.6%); flexural area involvement was mainly found in the adolescent group. The mean disease duration was 2.3 times longer in the adult group than in the adolescent group. The histopathologic features included hyperkeratosis (95.0%), acanthosis (87.5%), and papillomatosis (77.5%) in the epidermis. In the adult group, only 10 specimens (52.6%) showed mild to moderate papillomatosis. There was no relationship between the histologic findings and disease duration; however, the former was associated with the anatomic site.
The present study is the first to present the clinical and histologic features of CRP according to age and anatomic site in Korean patients. The patients in this study more frequently had fungal infections (31%) than patients in a previous study (12.8%). Histologic changes were more prominent in the adolescent group than in the adult group and in the flexural area than in the non-flexural area.
融合性网状乳头瘤病（CRP）是一种罕见的皮肤病，其特征为色素沉着性鳞屑性斑疹或乳头瘤样丘疹，中央融合成融合性斑块或斑片，周边呈网状。文献中关于此疾病的报道较少。
本研究旨在根据解剖部位和年龄调查韩国CRP患者的临床和组织学特征。
我们回顾性分析了29例诊断为CRP患者的病历、临床照片和40张组织病理学切片。
纳入16名成年人和13名青少年。主要累及的解剖部位是躯干（89.7%）和腋窝（27.6%）；屈侧受累主要见于青少年组。成人组的平均病程是青少年组的2.3倍。组织病理学特征包括表皮角化过度（95.0%）、棘层肥厚（87.5%）和乳头瘤样增生（77.5%）。在成人组中，只有10个标本（52.6%）显示轻度至中度乳头瘤样增生。组织学表现与病程之间无相关性；然而，前者与解剖部位有关。
本研究首次呈现了韩国CRP患者根据年龄和解剖部位的临床和组织学特征。本研究中的患者真菌感染发生率（31%）高于先前研究中的患者（12.8%）。青少年组的组织学改变比成人组更明显，屈侧比非屈侧更明显。
