Lee Sang-Sin, Jung Nam-Ji, Im Myung, Lee Young, Seo Young-Joon, Lee Jeung-Hoon
Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea.
Ann Dermatol. 2011 Oct;23(Suppl 2):S208-10. doi: 10.5021/ad.2011.23.S2.S208. Epub 2011 Oct 31.
Acanthosis nigricans is a symmetric eruption characterized by the presence of a hyperpigmented, velvety cutaneous thickening, that can develop on any part of the body, but characteristically affects the flexural areas of the body. The velvety hyperkeratotic lesions can be located on the dorsum of the hands and feet in dark-skinned people in the form of a variant of acanthosis nigricans called as acral acanthotic anomaly or acral type acanthosis nigricans. Although acanthosis nigricans is associated with malignant tumors, particularly gastric carcinoma, acral type acanthosis nigricans has never been reported to be associated with gastric adenocarcinoma. In our present study, we describe a case of 58-year-old man with acral type acanthosis nigricans and its association with carcinoma of the stomach; a marked improvement was seen in the skin condition of the patient with chemotherapy.
黑棘皮病是一种对称性皮疹，其特征为出现色素沉着过度、天鹅绒样的皮肤增厚，可发生于身体的任何部位，但典型地累及身体的屈侧部位。在肤色较深的人群中，天鹅绒样的角化过度性损害可出现在手足背部，表现为黑棘皮病的一种变异型，称为肢端棘皮症异常或肢端型黑棘皮病。尽管黑棘皮病与恶性肿瘤尤其是胃癌相关，但肢端型黑棘皮病从未被报道与胃腺癌相关。在我们目前的研究中，我们描述了一例58岁男性患肢端型黑棘皮病及其与胃癌的关联；患者经化疗后皮肤状况有明显改善。
