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面部瘢痕激光治疗中与治疗反应相关的重要因素:一项基于单机构的回顾性研究。

The Important Factors Associated with Treatment Response in Laser Treatment of Facial Scars: A Single-Institution Based Retrospective Study.

作者信息

Lim Youngkyoung, Park Ji-Hye, Lee Dong-Youn, Hwang Na-Young, Ahn Soohyun, Lee Jong Hee

机构信息

Department of Dermatology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Statistics and Data Center, Samsung Medical Center, Seoul, Korea.

出版信息

Ann Dermatol. 2019 Feb;31(1):6-13. doi: 10.5021/ad.2019.31.1.6. Epub 2019 Jan 2.

Abstract

BACKGROUND

There is increased interest in laser treatment of facial scars.

OBJECTIVE

To determine the factors associated with treatment response.

METHODS

We conducted an institution-based retrospective study by including the patients treated with laser for facial scars from 2012 to 2015. Treatment methods were determined with an algorithm according to individual scar characteristics. In each treatment session, either a 595-nm pulsed-dye laser or a non-ablative fractional laser was used, often in combination with a corticosteroid injection. We evaluated treatment responses based on the number of treatment sessions required to reach the treatment endpoint. Data were analyzed using multinomial logistic regression analysis to examine the association between treatment response and various factors of the scar.

RESULTS

A total of eighty-four scars were analyzed. The onset of treatment (defined as the period between the injury and treatment initiation), used laser modality, and the location of the scar were all found to be significantly associated with treatment responses. Early implementation was more likely to provide better treatment response. Scars on the perioral area were more likely to be associated with worse treatment response.

CONCLUSION

The important factors for the treatment response in facial scars were the location of the scar and the timing of the initiation of treatment. Such information can be used to predict treatment response and tailor the treatment plan to the patient, depending on scar characteristics.

摘要

背景

人们对激光治疗面部瘢痕的兴趣日益增加。

目的

确定与治疗反应相关的因素。

方法

我们进行了一项基于机构的回顾性研究,纳入了2012年至2015年接受激光治疗面部瘢痕的患者。根据个体瘢痕特征,通过算法确定治疗方法。在每次治疗中,通常联合皮质类固醇注射,使用595纳米脉冲染料激光或非剥脱性分数激光。我们根据达到治疗终点所需的治疗次数评估治疗反应。使用多项逻辑回归分析对数据进行分析,以检验治疗反应与瘢痕的各种因素之间的关联。

结果

共分析了84处瘢痕。治疗开始时间(定义为受伤与开始治疗之间的时间段)、所使用的激光类型以及瘢痕的位置均与治疗反应显著相关。早期进行治疗更有可能获得更好的治疗反应。口周区域的瘢痕更有可能与较差的治疗反应相关。

结论

面部瘢痕治疗反应的重要因素是瘢痕的位置和开始治疗的时间。这些信息可用于预测治疗反应,并根据瘢痕特征为患者制定个性化的治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e155/7992698/507e1c9f9c5d/ad-31-6-g001.jpg

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