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卡培他滨联合奥沙利铂治疗基底细胞癌

Capecitabine Plus Oxaliplatin Combination Therapy for Basal Cell Carcinoma.

作者信息

Rhee Jiyoung, Jo Jaemin, Han Sang-Hoon, Kwon Jung-Mi

机构信息

Division of Hematology-Oncology, Department of Internal Medicine, Jeju National University Hospital, Jeju, Korea.

出版信息

Ann Dermatol. 2019 Apr;31(2):201-203. doi: 10.5021/ad.2019.31.2.201. Epub 2019 Feb 28.

DOI:10.5021/ad.2019.31.2.201
PMID:33911569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7992662/
Abstract

No effective systemic chemotherapy is well-established in basal cell carcinoma. We report a case with three simultaneous malignancies: colon cancer, basal cell carcinoma, and smoldering multiple myeloma. The patient was treated with capecitabine and oxaliplatin after surgery for colon cancer. Surprisingly, he achieved a complete response for basal cell carcinoma. This is the first report of this chemotherapy regimen in basal cell carcinoma. This finding suggests that combination capecitabine and oxaliplatin can be a treatment option for patients unable to receive local therapy.

摘要

在基底细胞癌中,尚未确立有效的全身化疗方法。我们报告一例同时患有三种恶性肿瘤的病例:结肠癌、基底细胞癌和冒烟型多发性骨髓瘤。该患者在接受结肠癌手术后接受了卡培他滨和奥沙利铂治疗。令人惊讶的是,他的基底细胞癌实现了完全缓解。这是该化疗方案用于基底细胞癌的首例报告。这一发现表明,卡培他滨和奥沙利铂联合使用可能是无法接受局部治疗患者的一种治疗选择。

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1
Capecitabine Plus Oxaliplatin Combination Therapy for Basal Cell Carcinoma.卡培他滨联合奥沙利铂治疗基底细胞癌
Ann Dermatol. 2019 Apr;31(2):201-203. doi: 10.5021/ad.2019.31.2.201. Epub 2019 Feb 28.
2
The clinical and cost-effectiveness of oxaliplatin and capecitabine for the adjuvant treatment of colon cancer: systematic review and economic evaluation.奥沙利铂和卡培他滨辅助治疗结肠癌的临床疗效与成本效益:系统评价与经济学评估
Health Technol Assess. 2006 Nov;10(41):iii-iv, xi-xiv, 1-185. doi: 10.3310/hta10410.
3
Phase II Trial of Preoperative Radiation With Concurrent Capecitabine, Oxaliplatin, and Bevacizumab Followed by Surgery and Postoperative 5-Fluorouracil, Leucovorin, Oxaliplatin (FOLFOX), and Bevacizumab in Patients With Locally Advanced Rectal Cancer: 5-Year Clinical Outcomes ECOG-ACRIN Cancer Research Group E3204.局部晚期直肠癌患者术前放疗联合卡培他滨、奥沙利铂和贝伐单抗,随后手术及术后使用5-氟尿嘧啶、亚叶酸钙、奥沙利铂(FOLFOX)和贝伐单抗的II期试验:5年临床结果 ECOG-ACRIN癌症研究组E3204
Oncologist. 2015 Jun;20(6):615-6. doi: 10.1634/theoncologist.2015-0106. Epub 2015 Apr 29.
4
Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma: final results of the Southern Italy Cooperative Oncology Group Trial 0108.卡培他滨联合奥沙利铂用于老年转移性结直肠癌患者的一线治疗:意大利南部肿瘤协作组0108试验的最终结果
Cancer. 2005 Jul 15;104(2):282-9. doi: 10.1002/cncr.21167.
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XELOX (capecitabine plus oxaliplatin): active first-line therapy for patients with metastatic colorectal cancer.XELOX方案(卡培他滨联合奥沙利铂):转移性结直肠癌患者的一线有效治疗方案。
J Clin Oncol. 2004 Jun 1;22(11):2084-91. doi: 10.1200/JCO.2004.11.069.
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[Safety and effectiveness of oxaliplatin combined with capecitabine or oxaliplatin combined with S-1 neoadjuvant chemotherapy in the treatment of advanced gastric cancer].奥沙利铂联合卡培他滨或奥沙利铂联合S-1新辅助化疗治疗进展期胃癌的安全性和有效性
Zhonghua Wei Chang Wai Ke Za Zhi. 2021 Feb 25;24(2):138-144. doi: 10.3760/cma.j.cn.441530-20200721-00433.
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本文引用的文献

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Nationwide Trends in the Incidence of Melanoma and Non-melanoma Skin Cancers from 1999 to 2014 in South Korea.1999 年至 2014 年韩国全国范围内黑色素瘤和非黑色素瘤皮肤癌的发病率趋势。
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Do patient access schemes for high-cost cancer drugs deliver value to society?-lessons from the NHS Cancer Drugs Fund.高成本癌症药物的患者准入方案是否为社会带来了价值?——来自英国国家医疗服务体系癌症药物基金的经验教训。
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Metastatic basal cell carcinoma: prognosis dependent on anatomic site and spread of disease.转移性基底细胞癌:预后取决于发病部位和疾病的扩散情况。
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Vismodegib for the treatment of basal cell skin cancer.维莫德吉治疗基底细胞皮肤癌。
Am J Health Syst Pharm. 2013 Jun 15;70(12):1033-8. doi: 10.2146/ajhp120311.
6
Capecitabine to reduce nonmelanoma skin carcinoma burden in solid organ transplant recipients.卡培他滨降低实体器官移植受者非黑素瘤皮肤癌负担。
Dermatol Surg. 2013 Apr;39(4):634-45. doi: 10.1111/dsu.12049. Epub 2013 Feb 4.
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Vismodegib and the hedgehog pathway: a new treatment for basal cell carcinoma.维莫德吉与刺猬通路:基底细胞癌的一种新疗法。
Clin Ther. 2012 Oct;34(10):2039-50. doi: 10.1016/j.clinthera.2012.08.011. Epub 2012 Oct 1.
8
Efficacy and safety of vismodegib in advanced basal-cell carcinoma.维莫德吉治疗晚期基底细胞癌的疗效和安全性。
N Engl J Med. 2012 Jun 7;366(23):2171-9. doi: 10.1056/NEJMoa1113713.
9
XELOX vs. FOLFOX4 as second line chemotherapy in advanced pancreatic cancer.奥沙利铂联合卡培他滨对比奥沙利铂联合亚叶酸钙/氟尿嘧啶作为晚期胰腺癌二线化疗方案的疗效比较
Hepatogastroenterology. 2012 Nov-Dec;59(120):2635-9. doi: 10.5754/hge12181.
10
Systemic therapy for disseminated basal cell carcinoma: an uncommon manifestation of a common cancer.全身性治疗基底细胞癌播散:一种常见癌症的罕见表现。
Cancer Treat Rev. 2011 Oct;37(6):440-3. doi: 10.1016/j.ctrv.2010.12.002. Epub 2011 Jan 7.