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系统用阿维A和二苯环丙烯酮免疫疗法联合治疗顽固性病毒性疣

Treatment of Recalcitrant Viral Warts with Combination Therapy of Systemic Acitretin and Diphenylcyclopropenone Immunotherapy.

作者信息

Shin Dong Seok, Han Sung Soo, Kim Tae Lim, Jang Ju Wang, Seo Hyun-Min, Kim Joung Soo

机构信息

Department of Dermatology, Hanyang University Guri Hospital, Guri, Korea.

出版信息

Ann Dermatol. 2020 Jun;32(3):243-246. doi: 10.5021/ad.2020.32.3.243. Epub 2020 Apr 24.

DOI:10.5021/ad.2020.32.3.243
PMID:33911745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7992613/
Abstract

Viral warts are benign proliferations of the epithelium caused by human papilloma virus (HPV) infection. Diverse therapeutic options are available for viral warts, depending on extension and severity of the disease. We report a case of a 19-year-old man who presented with multiple viral warts on hands and feet for 5 years. He was treated at other clinics before visiting our hospital, but there was no improvement. We treated the lesions with a combination therapy of systemic acitretin and diphenylcyclopropenone (DPCP) immunotherapy for 6 months. A significant improvement was observed during the 12th week of therapy. Herein, we report a case of recalcitrant viral warts showing complete regression when a combination therapy of oral acitretin and immunotherapy was administered.

摘要

病毒疣是由人乳头瘤病毒（HPV）感染引起的上皮良性增生。根据疾病的范围和严重程度，病毒疣有多种治疗选择。我们报告一例19岁男性，其手足出现多发性病毒疣5年。在来我院就诊前，他曾在其他诊所接受治疗，但未见改善。我们采用全身性阿维A与二苯基环丙烯酮（DPCP）免疫疗法联合治疗这些损害6个月。在治疗的第12周观察到显著改善。在此，我们报告一例顽固性病毒疣患者，在给予口服阿维A与免疫疗法联合治疗后完全消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/7992613/727eaa8af11a/ad-32-243-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/7992613/cd4d7748b31e/ad-32-243-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/7992613/727eaa8af11a/ad-32-243-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/7992613/cd4d7748b31e/ad-32-243-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7eba/7992613/727eaa8af11a/ad-32-243-g002.jpg

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Treatment of Recalcitrant Viral Warts with Combination Therapy of Systemic Acitretin and Diphenylcyclopropenone Immunotherapy.系统用阿维A和二苯环丙烯酮免疫疗法联合治疗顽固性病毒性疣
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J Am Acad Dermatol. 2018 Aug;79(2):377-378. doi: 10.1016/j.jaad.2018.01.011. Epub 2018 Jan 12.
2
Acitretin for the treatment of recalcitrant plantar warts.阿维A治疗顽固性跖疣
Dermatol Online J. 2017 Mar 15;23(3):13030/qt721426pm.
3
Investigations of the efficacy of diphenylcyclopropenone immunotherapy for the treatment of warts.
Int J Dermatol. 2014 Dec;53(12):e567-71. doi: 10.1111/ijd.12688.
4
Acitretin in management of diffuse common warts: a case report.阿维 A 酯治疗泛发性寻常疣：病例报告。
Dermatol Ther. 2011 Nov-Dec;24(6):581-3. doi: 10.1111/j.1529-8019.2012.01408.x.
5
Use of acitretin in the treatment of resistant viral warts.阿维 A 酯治疗耐药性病毒性疣。
J Dermatolog Treat. 2011 Aug;22(4):194-6. doi: 10.3109/09546631003674339. Epub 2010 May 5.
6
Treatment of extensive and recalcitrant viral warts with acitretin.阿维A治疗广泛性及顽固性病毒疣
Int J Dermatol. 2006 Apr;45(4):480-2. doi: 10.1111/j.1365-4632.2005.02643.x.
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Complete remission of recalcitrant viral warts under oral isotretinoin in a patient with low-grade B-cell lymphoma.一名低度B细胞淋巴瘤患者口服异维A酸后顽固性病毒疣完全缓解。
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