Zhong Ming, Yang Yi-Ru, Zhang Yong-Ze, Yan Sun-Jie
Department of Endocrinology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People's Republic of China.
Fujian Diabetes Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, Fujian, People's Republic of China.
Diabetes Metab Syndr Obes. 2021 Apr 22;14:1763-1772. doi: 10.2147/DMSO.S303096. eCollection 2021.
This study aimed to assess association between change in urine albumin-to-creatinine ratio (UACR) and the risk of diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus.
A retrospective study was performed, which included 185 individuals with type 2 diabetes. At baseline, and at two-year follow-up, we collected basic data, recorded symptoms and signs of DPN, measured biochemical indicators, composite motor nerve conduction velocity (composite MCV), and composite sensory nerve conduction velocity (composite SCV).
Changes of composite SCV, MCV and TCSS among different changes in UACR in patients without DPN and with DPN were not significantly different. An increase in UACR ≥30% (OR 3.059, 95%; CI: 1.012-9.249) suggested a risk for new-onset DPN. Based on ROC curve analysis, the areas under the curve were 0.654 ± 0.066 for change of UACR levels in non-DPN patients.
Change in UACR and NCV was not related in patients without DPN and with DPN; change in UACR ≥30% suggested a risk for new-onset DPN.
本研究旨在评估2型糖尿病患者尿白蛋白肌酐比值（UACR）变化与糖尿病周围神经病变（DPN）风险之间的关联。
进行了一项回顾性研究，纳入185例2型糖尿病患者。在基线及两年随访时，收集基础数据，记录DPN的症状和体征，测量生化指标、复合运动神经传导速度（复合MCV）和复合感觉神经传导速度（复合SCV）。
无DPN和有DPN患者中，不同UACR变化组间的复合SCV、MCV和多伦多临床神经病变评分系统（TCSS）变化无显著差异。UACR升高≥30%（比值比3.059，95%置信区间：1.012 - 9.249）提示新发DPN的风险。基于ROC曲线分析，非DPN患者UACR水平变化的曲线下面积为0.654±0.066。
无DPN和有DPN患者中，UACR变化与神经传导速度（NCV）无关；UACR升高≥30%提示新发DPN的风险。
