Li Dafei, Zhao Haiyan, Cui Zhong-Kai, Tian Guangyong
Department of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases, Guangzhou, China.
Front Pharmacol. 2021 Apr 12;12:620921. doi: 10.3389/fphar.2021.620921. eCollection 2021.
Hearing loss is a major unresolved problem in the world, which has brought a heavy burden to society, economy, and families. Hair cell damage and loss mediated by oxidative stress are considered to be important causes of hearing loss. The nuclear factor erythroid 2-related factor 2 (Nrf2) is a major regulator of antioxidant capacity and is involved in the occurrence and development of a series of toxic and chronic diseases associated with oxidative stress. In recent years, studies on the correlation between hearing loss and Nrf2 target have continuously broadened our knowledge, and Nrf2 has become a new strategic target for the development and reuse of hearing protection drugs. This review summarized the correlation of Nrf2 in various types of hearing loss, and the role of drugs in hearing protection through Nrf2 from the literature.
听力损失是全球一个尚未解决的重大问题，给社会、经济和家庭带来了沉重负担。氧化应激介导的毛细胞损伤和丢失被认为是听力损失的重要原因。核因子红细胞2相关因子2（Nrf2）是抗氧化能力的主要调节因子，参与一系列与氧化应激相关的毒性和慢性疾病的发生发展。近年来，关于听力损失与Nrf2靶点之间相关性的研究不断拓宽我们的认知，Nrf2已成为听力保护药物研发和再利用的新战略靶点。本综述从文献中总结了Nrf2在各类听力损失中的相关性，以及药物通过Nrf2发挥听力保护作用的情况。
