Bagchi Sudeshna, Kundu Sanchita, Chatterjee Arunit, Chatterjee Rudra Prasad
Department of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research, Kolkata, West Bengal, India.
Int J Appl Basic Med Res. 2021 Apr-Jun;11(2):111-113. doi: 10.4103/ijabmr.IJABMR_438_19. Epub 2021 Apr 8.
Granular cell tumor (GCT) is a rare benign tumor chiefly affecting the orofacial region, especially tongue. The origin of this neoplasia, after remaining a controversy for years, was finally identified to be from Schwann cell or neuroendocrine cell. They usually present as asymptomatic, firm, sessile, submucosal, solitary, or multiple nodule/papule like lesions. Histopathologically, the presence of sheets, cords or nests of large cells having abundant, eosinophilic granular cytoplasm, and pseudoepitheliomatous hyperplasia are the characteristic features of this neoplasm. Immunohistochemical stains such as S100, Cluster of differentiation 68, neuron-specific enolase, and laminin also aid in the proper diagnosis of granular cells. We hereby present a case of GCT in a 50-year-old male, which had a unique exophytic appearance, probably being only the second to be reported till date.
颗粒细胞瘤（GCT）是一种罕见的良性肿瘤，主要累及口面部区域，尤其是舌部。这种肿瘤的起源在多年来一直存在争议，最终被确定为来自施万细胞或神经内分泌细胞。它们通常表现为无症状、质地坚硬、无蒂、黏膜下、单发或多发的结节/丘疹样病变。组织病理学上，存在成片、成索或成巢状的大细胞，其细胞质丰富、嗜酸性且呈颗粒状，以及假上皮瘤样增生是该肿瘤的特征性表现。免疫组织化学染色如S100、分化簇68、神经元特异性烯醇化酶和层粘连蛋白也有助于颗粒细胞的正确诊断。我们在此报告一例50岁男性的颗粒细胞瘤病例，其具有独特的外生性外观，可能是迄今为止报道的第二例。
