Rose Barry, Tamvakopoulos George S, Yeung Eric, Pollock Robin, Skinner John, Briggs Timothy, Cannon Steven
London Bone and Soft-Tissue Tumour Unit, Royal National Orthopaedic Hospital NHS Trust, Brockley Hill, Stanmore, Middlesex HA7 4LP, UK.
Sarcoma. 2009;2009:765927. doi: 10.1155/2009/765927. Epub 2010 Feb 7.
Granular Cell Tumours are rare mesenchymal soft tissue tumours that arise throughout the body and are believed to be of neural origin. They often present as asymptomatic, slow-growing, benign, solitary lesions but may be multifocal. 1-2% of cases are malignant and can metastasise. Described series in the literature are sparse. We identified eleven cases in ten patients treated surgically and followed-up for a period of over 6 years in our regional bone and soft tissue tumour centre. Five tumours were located in the lower limb, four in the upper limb, and two in the trunk. Mean patient age was 31.2 years (range 8-55 years). Excision was complete in one case, marginal in five cases and intralesional in five cases. No patients required postoperative adjuvant treatment. Mean follow-up was 19.3 months (range 1-37 months). One case was multifocal, but there were no cases of local recurrence or malignancy. Histopathological and immunohistochemical analysis revealed the classical granular cell tumour features in all cases. We believe this case series to be the largest of its type in patients presenting to an orthopaedic soft tissue tumour unit. We present our findings and correlate them with findings of other series in the literature.
颗粒细胞瘤是一种罕见的间叶性软组织肿瘤，可发生于全身各处，被认为起源于神经。它们通常表现为无症状、生长缓慢、良性的孤立性病变，但也可能是多灶性的。1%-2%的病例为恶性，可发生转移。文献中报道的病例系列较少。我们在我们地区的骨与软组织肿瘤中心，识别出10例接受手术治疗并随访6年以上的患者中的11个病例。5个肿瘤位于下肢，4个位于上肢，2个位于躯干。患者平均年龄为31.2岁（范围8-55岁）。1例完整切除，5例边缘切除，5例病损内切除。没有患者需要术后辅助治疗。平均随访时间为19.3个月（范围1-37个月）。1例为多灶性，但无局部复发或恶性病例。组织病理学和免疫组织化学分析在所有病例中均显示出典型的颗粒细胞瘤特征。我们认为这个病例系列是向骨科软组织肿瘤科室就诊的患者中同类病例中最大的。我们展示我们的研究结果，并将它们与文献中其他系列的研究结果进行对比。
