来自波斯湾的（物质）对紫杉醇诱导的小鼠神经病变性疼痛的影响。 注：原文中“from the Persian Gulf”前似乎缺少关键信息，比如某种物质等，这里按字面意思翻译并补充了括号内容使句子更通顺。
The Effect of from the Persian Gulf on Neuropathy Pain Induced by Paclitaxel in Mice.
作者信息
Yegdaneh Afsaneh, Saeedi Anahita, Shahmiveh Tanin, Vaseghi Golnaz
机构信息
Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Adv Biomed Res. 2020 Dec 23;9:79. doi: 10.4103/abr.abr_183_20. eCollection 2020.
BACKGROUND
Marine seaweeds are a famous type of traditional food containing various kinds of secondary metabolites. These organisms have different biological activities such as antitumor, antiviral, and antioxidant. The aim of this study was to investigate the effects of total extract of on neuropathy pain induced by paclitaxel in mice.
MATERIALS AND METHODS
was collected from the Persian Gulf. The seaweed was extracted by maceration with methanol-ethyl acetate (1:1) solvent. The effect of the extract on neuropathy pain induced by paclitaxel was analyzed. All results were analyzed by one-way analysis of variance.
RESULTS
Acute administration of extract (100 and 200 mg/kg intraperitoneally [i.p.]) 30 min before the test on the 11 day significantly reduced the duration of paw licking ( < 0.001).
CONCLUSIONS
Chronic treatment with extract (100, 150, and 200 mg/kg i.p.) from the 6 day until the 10 day reduced the duration of paw licking. Therefore, should be considered for further treatment of neuropathy.
背景
海洋海藻是一种著名的传统食物，含有多种次生代谢产物。这些生物具有不同的生物活性，如抗肿瘤、抗病毒和抗氧化活性。本研究的目的是探讨[海藻名称未给出]总提取物对紫杉醇诱导的小鼠神经病理性疼痛的影响。
材料与方法
[海藻名称未给出]采自波斯湾。海藻用甲醇 - 乙酸乙酯（1:1）溶剂浸渍提取。分析提取物对紫杉醇诱导的神经病理性疼痛的影响。所有结果采用单因素方差分析。
结果
在第11天测试前30分钟腹腔注射（i.p.）[海藻名称未给出]提取物（100和200毫克/千克）可显著缩短舔爪持续时间（P < 0.001）。
结论
从第6天至第10天腹腔注射（i.p.）[海藻名称未给出]提取物（100、150和200毫克/千克）进行慢性治疗可缩短舔爪持续时间。因此，[海藻名称未给出]应考虑用于神经病变的进一步治疗。
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