• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

来自波斯湾海藻的细胞毒性磺基喹喔啉基甘油

Cytotoxic Sulfoquinovosyl Glycerols from the Seaweed from Persian Gulf.

作者信息

Sajjadi Seyed Ebrahim, Ghobeishavi Sahar, Yegdaneh Afsaneh

机构信息

Department of Pharmacognosy and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

Adv Biomed Res. 2024 Mar 28;13:22. doi: 10.4103/abr.abr_103_23. eCollection 2024.

DOI:10.4103/abr.abr_103_23
PMID:38808322
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11132194/
Abstract

BACKGROUNDS

Seaweeds are an important source of marine organisms that produce a lot of bioactive compounds.

MATERIALS AND METHODS

In this research, the seaweed was collected from Bushehr province of Persian Gulf of Iran. The seaweed was extracted by methanol:ethyl acetate (1:1) using maceration method. The compounds were isolated with different column chromatography and HPLC(High Performance Liquid Chromatography) by silica gel and hexane:ethyl acetate as mobile phase.

RESULTS

The isolated compounds were elucidated structurally by various 1 and 2 D-NMR and MS spectra. Besides the cytotoxicity test was done against HeLa using standard MTT assay and normal cells.

CONCLUSION

It afforded four known sulfoquinovosyl diacylglycerides and fucosterol. Compounds 1-5 showed cytotoxic effects against HeLa and HUVEC cell lines, with IC50 values of 12.2 ± 2.3, 25.8 ± 3.7, 14.9 ± 2.6, 9.8 ± 1.2 μM, and 5.6 ± 1.2, respectively.

摘要

背景

海藻是产生大量生物活性化合物的海洋生物的重要来源。

材料与方法

本研究中，海藻采集自伊朗波斯湾的布什尔省。采用浸渍法用甲醇：乙酸乙酯（1:1）对海藻进行提取。通过不同的柱色谱法以及以硅胶为固定相、正己烷：乙酸乙酯为流动相的高效液相色谱法（HPLC）分离化合物。

结果

通过各种一维和二维核磁共振光谱以及质谱对分离得到的化合物进行结构解析。此外，使用标准MTT法对HeLa细胞和正常细胞进行了细胞毒性测试。

结论

得到了四种已知的磺基喹喔啉二酰基甘油和岩藻甾醇。化合物1 - 5对HeLa和人脐静脉内皮细胞系显示出细胞毒性作用，IC50值分别为12.2±2.3、25.8±3.7、14.9±2.6、9.8±1.2 μM和5.6±1.2。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e80b/11132194/b0c5069bda75/ABR-13-22-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e80b/11132194/b0c5069bda75/ABR-13-22-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e80b/11132194/b0c5069bda75/ABR-13-22-g001.jpg

相似文献

1
Cytotoxic Sulfoquinovosyl Glycerols from the Seaweed from Persian Gulf.来自波斯湾海藻的细胞毒性磺基喹喔啉基甘油
Adv Biomed Res. 2024 Mar 28;13:22. doi: 10.4103/abr.abr_103_23. eCollection 2024.
2
Bioassay-guided isolation of glycolipids from the seaweed .生物测定引导下从海藻中分离糖脂。
Res Pharm Sci. 2020 Oct 19;15(5):473-480. doi: 10.4103/1735-5362.297850. eCollection 2020 Oct.
3
Cytotoxicity of Partitions against Breast and Cervical Cancer Cell Lines.不同分区对乳腺癌和宫颈癌细胞系的细胞毒性
Adv Biomed Res. 2018 Mar 27;7:43. doi: 10.4103/abr.abr_259_16. eCollection 2018.
4
Anti-tuberculosis and cytotoxic evaluation of the seaweed .海藻的抗结核及细胞毒性评估
Res Pharm Sci. 2018 Feb;13(1):30-37. doi: 10.4103/1735-5362.220965.
5
Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line.海藻中含岩藻甾醇部分对乳腺癌和结肠癌细胞系的细胞毒性
Pharmacogn Mag. 2012 Jan;8(29):60-4. doi: 10.4103/0973-1296.93327.
6
Phytochemical and biological evaluation of some Sargassum species from Persian Gulf.对波斯湾一些马尾藻属物种的植物化学和生物学评估。
Res Pharm Sci. 2016 May-Jun;11(3):243-9.
7
The effect of different partitions of seaweed Sargassum plagyophylum on depression behavior in mice model of despair.不同部位的海蒿子对绝望小鼠模型抑郁行为的影响
J Complement Integr Med. 2019 May 24;16(4):/j/jcim.2019.16.issue-4/jcim-2018-0207/jcim-2018-0207.xml. doi: 10.1515/jcim-2018-0207.
8
A New Taraxastane Triterpene from with Cytotoxic Activity Against Prostate Cancer Cells.一种来自具有抗前列腺癌细胞细胞毒活性的新蒲公英甾烷三萜。
Iran J Pharm Res. 2018 Winter;17(1):336-342.
9
Cytotoxicity and antimicrobial activity of marine macro algae (Dictyotaceae and Ulvaceae) from the Persian Gulf.来自波斯湾的海洋大型藻类（网地藻科和石莼科）的细胞毒性和抗菌活性
Cytotechnology. 2016 Oct;68(5):1717-26. doi: 10.1007/s10616-015-9921-6. Epub 2015 Oct 27.
10
The Effect of from the Persian Gulf on Neuropathy Pain Induced by Paclitaxel in Mice.来自波斯湾的（物质）对紫杉醇诱导的小鼠神经病变性疼痛的影响。 注：原文中“from the Persian Gulf”前似乎缺少关键信息，比如某种物质等，这里按字面意思翻译并补充了括号内容使句子更通顺。
Adv Biomed Res. 2020 Dec 23;9:79. doi: 10.4103/abr.abr_183_20. eCollection 2020.

引用本文的文献

1
The Benthic Dinoflagellate (Dinophyceae) Produces an Array of Compounds with Antineoplastic Activity in Cells of Tumor Origin.底栖甲藻（甲藻纲）在肿瘤来源细胞中产生一系列具有抗肿瘤活性的化合物。
Mar Drugs. 2025 Mar 14;23(3):127. doi: 10.3390/md23030127.

本文引用的文献

1
Effects of hydroalcoholic, methanolic, and hexane extracts of brown algae on scopolamine-induced memory impairment and learning deficit in rodents.褐藻水醇提取物、甲醇提取物和己烷提取物对东莨菪碱诱导的啮齿动物记忆损伤和学习缺陷的影响。
Res Pharm Sci. 2023 Mar 10;18(3):292-302. doi: 10.4103/1735-5362.371585. eCollection 2023 May-Jun.
2
Ultrasound-assisted extraction of alginic acid from Sargassum angustifolium harvested from Persian Gulf shores using response surface methodology.采用响应面法从波斯湾海岸收获的狭叶马尾藻中超声辅助提取海藻酸
Int J Biol Macromol. 2023 Jan 31;226:660-669. doi: 10.1016/j.ijbiomac.2022.12.070. Epub 2022 Dec 13.
3
Antifungal and Larvicidal Activities of Phlorotannins from Brown Seaweeds.
褐藻多酚的抗真菌和杀幼虫活性。
Mar Drugs. 2021 Apr 16;19(4):223. doi: 10.3390/md19040223.
4
The Effect of from the Persian Gulf on Neuropathy Pain Induced by Paclitaxel in Mice.来自波斯湾的（物质）对紫杉醇诱导的小鼠神经病变性疼痛的影响。 注：原文中“from the Persian Gulf”前似乎缺少关键信息，比如某种物质等，这里按字面意思翻译并补充了括号内容使句子更通顺。
Adv Biomed Res. 2020 Dec 23;9:79. doi: 10.4103/abr.abr_183_20. eCollection 2020.
5
Pharmaceutical and Nutraceutical Potential Applications of ...在药品和营养保健品方面的潜在应用。
Biomed Res Int. 2020 Oct 14;2020:2417410. doi: 10.1155/2020/2417410. eCollection 2020.
6
Potential Use of Marine Seaweeds as Prebiotics: A Review.海洋海藻作为益生元的潜在用途：综述
Molecules. 2020 Feb 24;25(4):1004. doi: 10.3390/molecules25041004.
7
Manufacturing of nanoliposomal extract from algae and investigating its release behavior and antioxidant activity.从藻类中制备纳米脂质体提取物并研究其释放行为和抗氧化活性。
Food Sci Nutr. 2019 Dec 6;8(1):299-310. doi: 10.1002/fsn3.1306. eCollection 2020 Jan.
8
The effect of different partitions of seaweed Sargassum plagyophylum on depression behavior in mice model of despair.不同部位的海蒿子对绝望小鼠模型抑郁行为的影响
J Complement Integr Med. 2019 May 24;16(4):/j/jcim.2019.16.issue-4/jcim-2018-0207/jcim-2018-0207.xml. doi: 10.1515/jcim-2018-0207.
9
Physicochemical characterization, antioxidant and hypoglycemic activities of selenized polysaccharides from Sargassum pallidum.硒化马尾藻多糖的理化性质表征、抗氧化和降血糖活性。
Int J Biol Macromol. 2019 Jul 1;132:308-315. doi: 10.1016/j.ijbiomac.2019.03.138. Epub 2019 Mar 22.
10
Anti-tuberculosis and cytotoxic evaluation of the seaweed .海藻的抗结核及细胞毒性评估
Res Pharm Sci. 2018 Feb;13(1):30-37. doi: 10.4103/1735-5362.220965.