Aksakal Ceyhun, Beyhan Murat, Gökçe Erkan
Gaziosmanpaşa University Faculty of Medicine, Department of Otorhinolaryngology, Tokat, Turkey.
Gaziosmanpaşa University Faculty of Medicine, Department of Radiology, Tokat, Turkey.
Turk Arch Otorhinolaryngol. 2021 Mar;59(1):54-64. doi: 10.4274/tao.2020.5811. Epub 2021 Mar 26.
The pathogenesis of paranasal sinus osteoma (PSO) has not been fully elucidated. It is thought that both embryological and developmental factors play a role in the etiology. The aim of the present study was to investigate the association of frequency and localization of PSOs detected on computed tomography (CT) examination with osteoma presence.
In this retrospective study conducted in December 2017 through March 2020 in Gaziosmanpaşa University Faculty of Medicine, images of a total of 18,867 patients who underwent paranasal sinus, maxillofacial CT and brain CT angiography were reviewed for the presence of PSOs. Sizes of PSOs and accompanying mucosal pathologies were identified. Associations between PSOs and paranasal sinus variations were evaluated statistically compared to the control group (200 patients without PSO).
A total of 176 patients (0.92%) were found to have PSO. Average age of the patients with PSO was 59.9 years (range: 18-93). PSOs were unilateral in 152 patients while 24 patients had multiple osteomas. Female/male ratio was 1.1/1. PSOs were most commonly located in the frontal sinuses. Frequencies of vertical concha bullosa, secondary middle turbinate, twisted uncinate, supraorbital ethmoid cell, intersinus septal cell, ethmoidomaxillary cell, Haller's cell, frontal sinus hypoplasia and sphenoid sinus hypoplasia were significantly higher in the patient group compared to the control group.
Higher or lower incidence rates of some anatomic variations in the patients with PSO could be explained by the possible effects of genetic and/or environmental factor. Additional studies are needed to evaluate these possible associations.
鼻窦骨瘤（PSO）的发病机制尚未完全阐明。人们认为胚胎学和发育因素在其病因中均起作用。本研究的目的是探讨计算机断层扫描（CT）检查中检测到的PSO的频率和定位与骨瘤存在之间的关联。
在2017年12月至2020年3月于加济奥斯曼帕夏大学医学院进行的这项回顾性研究中，对总共18867例行鼻窦、颌面CT及脑CT血管造影的患者图像进行了PSO检查。确定了PSO的大小及伴随的黏膜病变。与对照组（200例无PSO患者）相比，对PSO与鼻窦变异之间的关联进行了统计学评估。
共发现176例患者（0.92%）患有PSO。PSO患者的平均年龄为59.9岁（范围：18 - 93岁）。152例患者的PSO为单侧，24例患者有多发骨瘤。男女比例为1.1/1。PSO最常见于额窦。与对照组相比，患者组中垂直泡状鼻甲、继发中鼻甲、扭曲钩突、眶上筛窦气房、鼻窦间隔气房、筛上颌气房、哈勒气房、额窦发育不全和蝶窦发育不全的发生率显著更高。
PSO患者某些解剖变异的发生率较高或较低可能由遗传和/或环境因素的潜在影响来解释。需要进一步研究来评估这些可能的关联。
