中国脑胶质瘤患者的健康相关生活质量。
Health-related quality of life in glioma patients in China.
机构信息
Department of Neurosurgery, Xijing Institute of Clinical Neuroscience, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
出版信息
BMC Cancer. 2010 Jun 18;10:305. doi: 10.1186/1471-2407-10-305.
BACKGROUND
Health-related quality of life (HRQOL) has been increasingly emphasized in cancer patients. There are no reports comparing baseline HRQOL of different subgroups of glioma patients prior to surgery.
METHODS
HRQOL assessments by the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30, version 3.0), the Mini-Mental State Examination and Karnofsky Performance Status were obtained from glioma patients prior to surgery.
RESULTS
Ninety-two pathologically confirmed glioma patients were recruited. There were 84.8% patients with emotional impairment, 75% with social and cognitive impairment, 70.7% with physical impairment, and 50% with role impairment. Eighty-two percent of patients reported fatigue symptoms, 72.8% reported pain, 50% reported appetite loss, 39.1% reported insomnia, and 36.9% reported nausea/vomiting, whereas other symptoms (dyspnea, diarrhea, constipation) in the QLQ-C30 were reported by fewer than 30% of patients. Fatigue and pain symptoms and all "functioning" scales were strongly correlated with global health status/quality of life (QoL). Fatigue was strongly related to all functioning scales, pain, appetite loss, and global health status/QoL. No difference in baseline HRQOL prior to surgery was reported between females and males, among different lesion locations, or between normal- and abnormal-cognition subgroups of glioma patients. Age, KPS, WHO grade, and tumor recurrence significantly affected HRQOL in glioma patients.
CONCLUSIONS
These data provided the baseline HRQOL in glioma patients prior to surgery in China. Most pre-surgery glioma patients indicated emotional, social, cognitive, physical, and role impairment. Fatigue, pain, appetite loss, insomnia, and nausea/vomiting were common in these patients. The fatigue and pain symptoms and all types of functioning strongly affected global health status/QoL. Old age, worse performance status, WHO grade IV and tumor recurrence had deleterious effects on HRQOL.
背景
健康相关生活质量（HRQOL）在癌症患者中越来越受到重视。目前尚无报告比较手术前不同亚组脑胶质瘤患者的基线 HRQOL。
方法
通过标准中文版欧洲癌症研究与治疗组织生活质量核心问卷 30 项（EORTC QLQ-C30，第 3.0 版）、简易精神状态检查和卡诺夫斯基表现状态对术前脑胶质瘤患者进行 HRQOL 评估。
结果
共纳入 92 例经病理证实的脑胶质瘤患者。84.8%的患者存在情绪障碍，75%存在社会和认知障碍，70.7%存在躯体障碍，50%存在角色障碍。82%的患者报告有疲劳症状，72.8%报告有疼痛，50%报告有食欲减退，39.1%报告有失眠，36.9%报告有恶心/呕吐，而 QLQ-C30 中的其他症状（呼吸困难、腹泻、便秘）少于 30%的患者报告。疲劳和疼痛症状以及所有“功能”量表与总体健康状况/生活质量（QoL）强烈相关。疲劳与所有功能量表、疼痛、食欲减退和总体健康状况/生活质量密切相关。术前 HRQOL 在女性和男性之间、不同病变部位之间或脑胶质瘤患者正常认知和异常认知亚组之间无差异。年龄、KPS、WHO 分级和肿瘤复发显著影响脑胶质瘤患者的 HRQOL。
结论
这些数据提供了中国脑胶质瘤患者术前的基线 HRQOL。大多数术前脑胶质瘤患者存在情绪、社会、认知、躯体和角色障碍。疲劳、疼痛、食欲减退、失眠和恶心/呕吐在这些患者中很常见。疲劳和疼痛症状以及所有类型的功能都强烈影响总体健康状况/生活质量。年龄较大、功能状态较差、WHO 分级 IV 和肿瘤复发对 HRQOL 有不良影响。
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