Huisman R, Okhuijsen-Pfeifer C, Mulder E Y H, Jongkind A, Cohen D, Bogers J P A M, van der Horst M Z, Luykx J J
Tijdschr Psychiatr. 2021;63(4):270-275.
To monitor the unique side effect pattern of clozapine, the Glasgow Antipsychotic Side-effect Scale for Clozapine (GASS-C) was developed in English and validated. This questionnaire was previously translated to Dutch, and revised, but not yet validated.
The current study concerns the validation of the second revision of the GASS-C-NL-R2 for the Dutch language.
Two Spearman correlation tests were conducted to compare GASS-C-NL-R2 with the Dutch version of the Liverpool University Neuroleptic Side-Effect Rating Scale (LUNSERS) at two time p´oints. There was one week between these two time points. The test-retest reliability was determined using a Spearman correlation test and Cronbach's alpha on the GASS-C-NL-R2 between the two time points. In addition, a factor analysis was performed.
Spearman's correlation coefficient between the GASS-C-NL-R2 and the LUNSERS was 0.830 (p < 0.001, n = 72) at the first time point and 0.684 (p < 0.001, n = 50) at the second time point. GASS-C-NL-R2 also had a strong test-retest reliability: Spearman's correlation coefficient was 0.680 (p < 0.001; n = 46), and Cronbach's alpha was 0.847, n = 78. Factor analysis showed that all questions were relevant.
The current study shows that GASS-C-NL-R2 is a valid and reliable questionnaire to monitor side effects related to clozapine with a relatively high prevalence. Future studies should focus on the practical utility of GASS-C-NL-R2 with a larger sample size.
为监测氯氮平独特的副作用模式，格拉斯哥氯氮平抗精神病药物副作用量表（GASS-C）已用英文编制并验证。该问卷先前已翻译成荷兰语并修订，但尚未验证。
本研究旨在验证荷兰语版GASS-C-NL-R2的第二次修订版。
进行了两次斯皮尔曼相关性检验，以在两个时间点比较GASS-C-NL-R2与荷兰版利物浦大学抗精神病药物副作用评定量表（LUNSERS）。这两个时间点之间间隔一周。使用斯皮尔曼相关性检验和两个时间点之间GASS-C-NL-R2的克朗巴哈系数来确定重测信度。此外，还进行了因子分析。
在第一个时间点，GASS-C-NL-R2与LUNSERS之间的斯皮尔曼相关系数为0.830（p < 0.001，n = 72），在第二个时间点为0.684（p < 0.001，n = 50）。GASS-C-NL-R2也具有很强的重测信度：斯皮尔曼相关系数为0.680（p < 0.001；n = 46），克朗巴哈系数为0.847，n = 78。因子分析表明所有问题都具有相关性。
本研究表明，GASS-C-NL-R2是一份有效且可靠的问卷，用于监测与氯氮平相关的副作用，且这些副作用的发生率相对较高。未来的研究应以更大样本量关注GASS-C-NL-R2的实际效用。
