Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
J Sleep Res. 2021 Dec;30(6):e13347. doi: 10.1111/jsr.13347. Epub 2021 Apr 28.
Neuroimaging and genetics studies have advanced our understanding of the neurobiology of sleep and its disorders. However, individual studies usually have limitations to identifying consistent and reproducible effects, including modest sample sizes, heterogeneous clinical characteristics and varied methodologies. These issues call for a large-scale multi-centre effort in sleep research, in order to increase the number of samples, and harmonize the methods of data collection, preprocessing and analysis using pre-registered well-established protocols. The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium provides a powerful collaborative framework for combining datasets across individual sites. Recently, we have launched the ENIGMA-Sleep working group with the collaboration of several institutes from 15 countries to perform large-scale worldwide neuroimaging and genetics studies for better understanding the neurobiology of impaired sleep quality in population-based healthy individuals, the neural consequences of sleep deprivation, pathophysiology of sleep disorders, as well as neural correlates of sleep disturbances across various neuropsychiatric disorders. In this introductory review, we describe the details of our currently available datasets and our ongoing projects in the ENIGMA-Sleep group, and discuss both the potential challenges and opportunities of a collaborative initiative in sleep medicine.
神经影像学和遗传学研究提高了我们对睡眠及其障碍的神经生物学的理解。然而，个体研究通常存在识别一致和可重复效应的局限性，包括样本量小、临床特征异质和方法多样。这些问题需要在睡眠研究中进行大规模的多中心努力，以增加样本数量，并使用预先注册的成熟方案协调数据收集、预处理和分析的方法。通过荟萃分析增强神经影像学遗传学（ENIGMA）联盟为跨个体站点合并数据集提供了一个强大的协作框架。最近，我们与来自 15 个国家的多个机构合作，启动了 ENIGMA-Sleep 工作组，开展大规模的全球神经影像学和遗传学研究，以更好地理解基于人群的健康个体中睡眠质量受损的神经生物学、睡眠剥夺的神经后果、睡眠障碍的病理生理学以及各种神经精神障碍中睡眠障碍的神经相关性。在这篇介绍性综述中，我们描述了我们目前可用数据集的详细信息以及我们在 ENIGMA-Sleep 组中的正在进行的项目，并讨论了睡眠医学中协作倡议的潜在挑战和机遇。
