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[抗高血压药物吲达帕胺的对照多中心试验]

[Controlled multicentric trial of the antihypertensive agent indapamide].

作者信息

Gragnoli G, Abate G, Guerrini M

出版信息

Minerva Med. 1977 Nov 10;68(54):3669-80.

PMID:339132
Abstract

Two-months' administration of 2.5 mg/day indapamide, preceded and followed by 2 weeks of a placebo, led to a significant fall in pressure values and normalisation of diastolic pressure in a high percentage of 47 subjects, mostly with essential hypertension, in a controlled multi-centre trial. Absence of toxic effects, tolerance and therapeutic activity at low doses recommend the drug for most cases of arterial hypertension.

摘要

在一项对照多中心试验中,对47名主要患有原发性高血压的受试者,先给予2周安慰剂,然后每天服用2.5毫克吲达帕胺2个月,之后再给予2周安慰剂,结果导致血压值显著下降,且高比例受试者的舒张压恢复正常。低剂量时无毒性作用、耐受性良好及具有治疗活性,这表明该药物适用于大多数动脉高血压病例。

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