Gragnoli G, Abate G, Guerrini M
Minerva Med. 1977 Nov 10;68(54):3669-80.
Two-months' administration of 2.5 mg/day indapamide, preceded and followed by 2 weeks of a placebo, led to a significant fall in pressure values and normalisation of diastolic pressure in a high percentage of 47 subjects, mostly with essential hypertension, in a controlled multi-centre trial. Absence of toxic effects, tolerance and therapeutic activity at low doses recommend the drug for most cases of arterial hypertension.
在一项对照多中心试验中，对47名主要患有原发性高血压的受试者，先给予2周安慰剂，然后每天服用2.5毫克吲达帕胺2个月，之后再给予2周安慰剂，结果导致血压值显著下降，且高比例受试者的舒张压恢复正常。低剂量时无毒性作用、耐受性良好及具有治疗活性，这表明该药物适用于大多数动脉高血压病例。
