Liu Shuang, Xiao Jing, Chen Ke, Xiao Wenqian, Li Bo
Chongqing Key Laboratory of Nano/Micro Composite Materials and Devices, Chongqing University of Science and Technology, Chongqing 401331.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2021 Apr 25;38(2):393-398. doi: 10.7507/1001-5515.202008057.
Cryogels are a type of hydrogel material which are fabricated by cryopolymerization at subzero temperature. Due to their unique macroporous structure, shape memory properties and injectability, cryogels have gained significant interest in the fields of tissue engineering for encouraging the repair and regeneration of injured tissues. In this review, the basic concepts relevant to cryogels are introduced, and then the fabrication principle, the process parameters and the unique properties of cryogel are discussed. Next, the latest advances of cryogels as three-dimensional scaffold for various tissue engineering applications are given. Finally, this review summarizes the current limitations of cryogels, and strategies to further improve their properties for tissue engineering. The purpose of this article is to provide a reference guide for the researchers in related fields.
冷冻凝胶是一种水凝胶材料，通过在零下温度下进行冷冻聚合制备而成。由于其独特的大孔结构、形状记忆特性和可注射性，冷冻凝胶在组织工程领域引起了极大的关注，有助于促进受损组织的修复和再生。在这篇综述中，介绍了与冷冻凝胶相关的基本概念，然后讨论了冷冻凝胶的制备原理、工艺参数和独特性能。接下来，给出了冷冻凝胶作为用于各种组织工程应用的三维支架的最新进展。最后，本综述总结了冷冻凝胶目前的局限性，以及进一步改善其用于组织工程的性能的策略。本文旨在为相关领域的研究人员提供参考指南。
