Department of Chemistry, University of Delhi, Delhi 110007, India.
School of Natural Sciences, University of Central Lancashire, Preston, PR1 2HE, UK.
Nanomedicine (Lond). 2021 May;16(11):883-894. doi: 10.2217/nnm-2020-0445. Epub 2021 Apr 29.
We investigated the application of fluorescein (FL)-entrapped magnetosomes, in other words, silica-coated iron oxide nanoparticles entrapped within niosomes (SIO/NIO), in magnetically assisted photodynamic therapy (PDT) . Panc-1 cells were treated with the magnetosomes, with and without external magnetic guidance, and irradiated with blue light. Upon photoactivation, the FL-entrapped magnetosomes can produce higher singlet oxygen in comparison to FL-entrapped micelles, probably due to the higher release tendency of the photosensitizer from the former. studies in Panc-1 cells revealed magnetically assisted enhancement in the cellular uptake of the magnetosomes. Magnetic assistance also led to enhancement in PDT efficiency in cells treated with the FL-entrapped magnetosomes and light, thus highlighting their potential in PDT.
我们研究了荧光素（FL）包裹磁小体，即包被于囊泡（SIO/NIO）内的二氧化硅包裹的氧化铁纳米粒子，在磁辅助光动力疗法（PDT）中的应用。用和不用外加磁场引导，将磁小体作用于 Panc-1 细胞，并用蓝光照射。光激活后，与 FL 包裹胶束相比，FL 包裹磁小体可以产生更高的单线态氧，这可能是由于前者具有更高的光敏剂释放趋势。在 Panc-1 细胞中的研究表明，磁辅助作用增强了磁小体的细胞摄取。磁辅助还提高了用 FL 包裹的磁小体和光处理的细胞中的 PDT 效率，因此突出了它们在 PDT 中的潜力。
