载脂蛋白 A1/载脂蛋白 B 比值与腹膜透析患者的急性冠脉综合征。

Apo A1/Apo B ratio and acute coronary syndrome among peritoneal dialysis patients.

机构信息

Department of Nephrology, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, PR China.

出版信息

Ren Fail. 2021 Dec;43(1):737-742. doi: 10.1080/0886022X.2021.1918556.

DOI:10.1080/0886022X.2021.1918556

PMID:33913384

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8901281/

Abstract

BACKGROUND

Acute coronary syndrome (ACS) is prevalent in continuous ambulatory peritoneal dialysis (CAPD) patients. However, the association between the apoprotein profile and ACS is not well known. Therefore, we aimed to investigate the relationship between apoproteins and ACS in CAPD patients.

METHODS

Eighty-one CAPD patients were included in this retrospective study. The primary endpoint was ACS. Predictors were baseline apoprotein levels, particularly the ratio of apoprotein A1 (Apo A1)/apoprotein B (Apo B). Cox regression was used to determine the relationship between Apo A1/Apo B and ACS.

RESULTS

During follow-up, 34 (41.98%) CAPD patients experienced an ACS. ACS patients had higher levels of total cholesterol ( = 0.03), low-density lipoprotein cholesterol (LDL-C) ( = 0.04), C-reactive protein ( = 0.01), and Apo B ( < 0.01). However, hemoglobin ( = 0.01) and Apo A1/Apo B ( < 0.01) were lower in the ACS group than the non-ACS group. Patients with Apo A1/Apo ≥ 1.105 experienced fewer ACS compared with those with Apo A1/Apo < 1.105 (33.33% 75.56%, = 0.03). In Cox regression, Apo A1/Apo B (RR, 0.06; 95% CI, 0.00-0.77; = 0.03) was independently associated with ACS.

CONCLUSIONS

Apo A1/Apo B was strongly associated with ACS and may be considered as a predictor of future ACS in CAPD patients.

摘要

背景

急性冠脉综合征（ACS）在持续非卧床腹膜透析（CAPD）患者中较为常见。然而，载脂蛋白谱与 ACS 的关系尚不清楚。因此，我们旨在研究 CAPD 患者载脂蛋白与 ACS 的关系。

方法

本回顾性研究纳入了 81 例 CAPD 患者。主要终点为 ACS。预测因子为基线载脂蛋白水平，特别是载脂蛋白 A1（Apo A1）/载脂蛋白 B（Apo B）比值。Cox 回归用于确定 Apo A1/Apo B 与 ACS 的关系。

结果

在随访期间，34 例（41.98%）CAPD 患者发生 ACS。ACS 患者的总胆固醇（=0.03）、低密度脂蛋白胆固醇（LDL-C）（=0.04）、C 反应蛋白（=0.01）和 Apo B（<0.01）水平较高。然而，ACS 组的血红蛋白（=0.01）和 Apo A1/Apo B（<0.01）水平低于非 ACS 组。Apo A1/Apo ≥ 1.105 的患者发生 ACS 的比例低于 Apo A1/Apo < 1.105 的患者（33.33%比 75.56%，=0.03）。在 Cox 回归中，Apo A1/Apo B（RR，0.06；95%CI，0.00-0.77；=0.03）与 ACS 独立相关。