Department of IVF Research and Training Center, Ege University School of Medicine, Izmir, Turkey.
Department of Obstetrics and Gynecology, Ege University School of Medicine, Izmir, Turkey.
J Obstet Gynaecol. 2022 Feb;42(2):276-280. doi: 10.1080/01443615.2021.1882973. Epub 2021 Apr 29.
Developments in embryo freezing techniques in recent years have increased the chance of pregnancy after frozen embryo transfers. In this study we aimed to compare the pregnancy outcomes between fresh (ET) and frozen-thawed embryo transfer (FET) and to evaluate the benefits of embryo freezing strategy for a woman of advanced age. A total of 513 ET cycles in women over the age of 35 years, including 397 fresh ET cycles and 116 FET cycles were reviewed. Mean age was 37.7 ± 2.91 years in FET cycles and 38 ± 2.8 in fresh cycles ( = .327). The patients undergoing FET cycles had higher oestradiol levels and progesterone levels on the day of trigger in their previous fresh cycles compared to that of fresh ET cycles (1675 pmol/L versus 991 pmol/L; 1.43 pmol/L versus 0.96 pmol/L; < .005, respectively). Biochemical pregnancy rates (43% versus 32%; = .048), clinical pregnancy rates (38% versus 29%; = .030) and live birth rates (30% versus 19.6%; = .013) were significantly higher in the FET than in the fresh ET over 35 years of age.IMPACT STATEMENT Ovarian stimulation commonly results in the generation of more embryos than are necessary for the fresh embryo transfer. Therefore, cryopreservation and subsequent replacement of frozen-thawed embryos is an integral part of assisted reproductive technique (ART) programs. As IVF technology improved, embryo freezing was performed to allow subsequent transfer if the fresh cycle was unsuccessful. Clinical pregnancy rates and live birth rates were found to be higher in frozen thawed embryo transfer group compared to fresh embryo transfer group over the age of 35. Frozen thawed embryo transfer seems to be a reasonable and favourable method compared to fresh embryo transfer in patients over 35 years.
近年来胚胎冷冻技术的发展提高了冷冻胚胎移植后的妊娠机会。本研究旨在比较新鲜胚胎移植（ET）和冷冻胚胎解冻移植（FET）的妊娠结局，并评估胚胎冷冻策略对高龄妇女的益处。回顾了 513 例年龄超过 35 岁的妇女的 ET 周期，包括 397 例新鲜 ET 周期和 116 例 FET 周期。FET 周期的平均年龄为 37.7 ± 2.91 岁，新鲜周期为 38 ± 2.8 岁（=.327）。与新鲜 ET 周期相比，接受 FET 周期的患者在前一次新鲜周期的扳机日雌二醇水平和孕酮水平更高（1675 pmol/L 比 991 pmol/L；1.43 pmol/L 比 0.96 pmol/L； < .005）。生化妊娠率（43%比 32%； =.048）、临床妊娠率（38%比 29%； =.030）和活产率（30%比 19.6%； =.013）在 FET 中均显著高于新鲜 ET 中。
声明 卵巢刺激通常会产生比新鲜胚胎移植所需的胚胎更多。因此，冷冻保存和随后替换冷冻解冻胚胎是辅助生殖技术（ART）项目的一个组成部分。随着 IVF 技术的提高，胚胎冷冻被用于在新鲜周期不成功的情况下进行后续移植。与新鲜胚胎移植组相比，年龄超过 35 岁的冷冻解冻胚胎移植组的临床妊娠率和活产率更高。与新鲜胚胎移植相比，冷冻解冻胚胎移植似乎是高龄患者更合理和有利的方法。
