单宁酸基金属酚醛网络在生物应用中的研究进展：综述。

Tannic acid-based metal phenolic networks for bio-applications: a review.

机构信息

Key Laboratory of Advanced Materials, Ministry of Education of China, School of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.

The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.

出版信息

J Mater Chem B. 2021 May 26;9(20):4098-4110. doi: 10.1039/d1tb00383f.

DOI:10.1039/d1tb00383f

PMID:33913461

Abstract

Tannic acid (TA), a large polyphenolic molecule, has long been known for use in food additives, antioxidants, bio-sorbents, animal feed and adhesives due to its intrinsic properties such as antioxidation, metal chelation, and polymerization. Recently, there has been a renewed interest in fabricating engineered advanced materials with TA modification for novel bio-applications. The modification process involves various interactions/reactions based on its diverse chemical structure, contributed by abundant aromatic rings and hydroxyl groups. In addition, the obtained composites are endowed with retained TA activity and novel enhanced properties. Therefore, the aim of this review is to highlight the recent biomedical application of TA-based metal phenolic networks (TA-MPNs) by focusing on their intrinsic properties and the endowed ability for novel engineered functional composites. The potential contributions of TA-MPNs in "Tumor Theranostics", "Anti-Bacterial Ability", "Wound Repair for Skin Regeneration" and "Bone Tissue Regeneration Applications" are summarized in this paper.

摘要

单宁酸（TA）是一种大型多酚分子，由于其内在的抗氧化、金属螯合和聚合等特性，长期以来一直被用于食品添加剂、抗氧化剂、生物吸附剂、动物饲料和粘合剂。最近，人们对利用 TA 改性来制造新型生物应用的工程先进材料重新产生了兴趣。该改性过程涉及到各种相互作用/反应，这是基于其多样的化学结构，丰富的芳环和羟基基团。此外，所得复合材料具有保留的 TA 活性和新的增强性能。因此，本综述的目的是通过关注 TA 基金属酚醛网络（TA-MPNs）的固有特性和赋予新型工程功能复合材料的能力，强调 TA 基金属酚醛网络（TA-MPNs）在“肿瘤治疗学”、“抗菌能力”、“皮肤再生的伤口修复”和“骨组织再生应用”中的最新生物医学应用。