流感疫苗接种对中年人群感染 SARS-CoV-2 风险的影响。
Impact of influenza vaccination on the risk of SARS-CoV-2 infection in a middle-aged group of people.
机构信息
Clinical Department of Internal Disease, Dermatology and Allergology in Zabrze, Medical University of Silesia, Katowice, Poland.
Medical Center Tysiaclecie, Katowice, Poland.
出版信息
Hum Vaccin Immunother. 2021 Sep 2;17(9):3126-3130. doi: 10.1080/21645515.2021.1913961. Epub 2021 Apr 29.
An observational study of a retrospective cohort was performed to assess the impact of influenza vaccination (IV) on the risk of SARS-CoV-2 infection in a population of middle-aged people for 8 weeks after IV and compared with an unvaccinated group. Data from 1098 middle-aged patients (53.7 ± 4.7 years) after IV and 1205 unvaccinated patients (50.1 ± 6.8 years) were analyzed based on medical documentation. The inclusion criteria were age between 40 - 60 years and IV in the period from 1-30 September 2020. The incidence of infection with SARS-CoV-2 was confirmed by PCR and the classification of ICD-10 (U07.1). After IV, patients had significantly fewer SARS-CoV-2 infections than the unvaccinated patients ( = .017). The hazard ratio was 0.74 (95% CI: 0.54-0.89). IV may partially reduce the risk of SARS-CoV-2 infection.
一项回顾性队列观察研究评估了流感疫苗接种（IV）对中年人群接种后 8 周内感染 SARS-CoV-2 的风险的影响，并与未接种组进行了比较。根据医疗记录，对 1098 名接种后中年患者（53.7±4.7 岁）和 1205 名未接种患者（50.1±6.8 岁）的数据进行了分析。纳入标准为年龄在 40-60 岁之间，且于 2020 年 9 月 1 日至 30 日期间接种 IV。通过 PCR 和 ICD-10（U07.1）分类确认 SARS-CoV-2 感染的发生率。接种 IV 后，患者感染 SARS-CoV-2 的情况明显少于未接种患者（ =.017）。风险比为 0.74（95%CI：0.54-0.89）。IV 可能部分降低 SARS-CoV-2 感染的风险。
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