Synthesis of Desacyl Furanmonogones A and B.

A strategy for the stereoselective synthesis of desacyl furanmonogones A and B has been achieved. The key steps in this synthesis are (1) an Fe(ClO)-mediated oxidative radical cyclization for construction of a -fused [5-6]-bicyclic core with a bridged lactone substitute, (2) a phosphorane-mediated rearrangement to convert the -fused [5-6]-bicyclic core to the corresponding -fused [5-6]-bicyclic core, and (3) a Au-catalyzed cascade reaction for formation of the 4,5--3(2)-furanone motif.