Dorobantu Dan M, Wadey Curtis A, Amir Nurul H, Stuart A Graham, Williams Craig A, Pieles Guido E
Children's Health and Exercise Research Centre (CHERC), University of Exeter, Exeter EX1 1TX, UK.
Population Health Sciences Department, University of Bristol, Bristol BS8 2PS, UK.
Diagnostics (Basel). 2021 Apr 1;11(4):635. doi: 10.3390/diagnostics11040635.
Speckle tracking echocardiography (STE) has gained importance in the evaluation of adult inherited cardiomyopathies, but its utility in children is not well characterized. We conducted a systematic review to evaluate the role of STE in pediatric inherited cardiomyopathies. PubMed, EMBASE, Web of Science, Scopus, CENTRAL and CINAHL databases were searched up to May 2020, for terms related to inherited cardiomyopathies and STE. Included were dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), left ventricular non-compaction (LVNC) and arrhythmogenic cardiomyopathy (ACM). A total of 14 cohorts were identified, of which six were in DCM, four in HCM, three in LVNC and one in ACM. The most commonly reported STE measurements were left ventricular longitudinal strain (S), circumferential strain (S), radial strain (S) and rotation/torsion/twist. S, S and were abnormal in all DCM and LVNC cohorts, but not in all HCM. Apical rotation and twist/torsion were increased in HCM, and decreased in LVNC. Abnormal STE parameters were reported even in cohorts with normal non-STE systolic/diastolic measurements. STE in childhood cardiomyopathies can detect early changes which may not be associated with changes in cardiac function detectable by non-STE methods. Longitudinal and circumferential strain should be introduced in the cardiomyopathy echocardiography protocol, reflecting current practice in adults.
斑点追踪超声心动图（STE）在成人遗传性心肌病的评估中已变得愈发重要，但其在儿童中的应用尚未得到充分描述。我们进行了一项系统评价，以评估STE在儿童遗传性心肌病中的作用。截至2020年5月，对PubMed、EMBASE、Web of Science、Scopus、CENTRAL和CINAHL数据库进行了检索，查找与遗传性心肌病和STE相关的术语。纳入的疾病包括扩张型心肌病（DCM）、肥厚型心肌病（HCM）、左心室心肌致密化不全（LVNC）和致心律失常性心肌病（ACM）。共确定了14个队列，其中6个队列研究DCM，4个队列研究HCM，3个队列研究LVNC，1个队列研究ACM。最常报告的STE测量指标为左心室纵向应变（S）、圆周应变（S）、径向应变（S）以及旋转/扭转/拧绞。在所有DCM和LVNC队列中，S、S和均异常，但并非所有HCM队列均如此。HCM患者的心尖旋转以及扭转/拧绞增加，LVNC患者则降低。即使在非STE收缩期/舒张期测量正常的队列中，也报告了异常的STE参数。儿童心肌病中的STE可检测到早期变化，这些变化可能与非STE方法可检测到的心脏功能变化无关。应将纵向和圆周应变引入心肌病超声心动图检查方案中，这反映了成人目前的做法。
