Rymut Haley E, Rund Laurie A, Bolt Courtni R, Villamil María B, Bender Diane E, Southey Bruce R, Johnson Rodney W, Rodriguez-Zas Sandra L
Department of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Department of Crop Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Animals (Basel). 2021 Apr 1;11(4):987. doi: 10.3390/ani11040987.
The effects of maternal immune activation (MIA) elicited by a prenatal stressor and postnatal metabolic or immune stressors on chemical and inflammatory biomarkers were studied in male and female pigs. Pigs exposed to MIA elicited by porcine reproductive and respiratory syndrome virus and matching controls were assigned at two months of age to fasting stress, immune stress, or a saline group. The serum levels of over 30 chemistry and immune analytes were studied. Significantly low levels of blood urea nitrogen were detected in females exposed to MIA, while the highest creatinine levels were identified in fasting females exposed to MIA. The levels of interferon gamma and interleukin 8 were highest in pigs exposed to postnatal immune challenge. The profiles suggest that MIA may sensitize pigs to postnatal stressors for some indicators while making them more tolerant of other stressors. Effectiveness of practices to ameliorate the impact of postnatal stressors on the physiology of the pig could be enhanced by considering the prenatal stress circumstances.
研究了产前应激源以及产后代谢或免疫应激源引发的母体免疫激活（MIA）对雄性和雌性猪的化学和炎症生物标志物的影响。将暴露于猪繁殖与呼吸综合征病毒引发的MIA的猪及其匹配对照组在两个月大时分为禁食应激组、免疫应激组或生理盐水组。研究了30多种化学和免疫分析物的血清水平。在暴露于MIA的雌性猪中检测到血尿素氮水平显著降低，而在暴露于MIA的禁食雌性猪中肌酐水平最高。在暴露于产后免疫挑战的猪中，γ干扰素和白细胞介素8的水平最高。这些数据表明，对于某些指标，MIA可能使猪对产后应激源敏感，而对于其他应激源则使其更具耐受性。考虑产前应激情况可提高改善产后应激源对猪生理影响的措施的有效性。
