Department of Animal Science, School of Veterinary Medicine, Kitasato University, Towada 034-8628, Japan.
Faculty of Veterinary Medicine, School of Veterinary Medicine, Kitasato University, Towada 034-8628, Japan.
Nutrients. 2021 Apr 1;13(4):1164. doi: 10.3390/nu13041164.
Olive oil is a functional food shown to have a variety of bioactive effects. Therefore, we expect it to be a novel functional food with an exercise-mimetic effect on skeletal muscles. This study aimed to investigate the effect of olive oil on the endurance capacity and muscle metabolism in mice. Mice fed a 7% (/) olive oil diet for eight weeks showed improved treadmill running endurance and increased intramuscular triacylglycerol (IMTG) accumulation in the gastrocnemius muscle compared to soybean oil diet-fed controls. The increase in running endurance with olive oil intake was independent of the muscle fiber type. To elucidate underlying the mechanism of elevated IMTG levels, we examined the expression levels of the genes related to lipid metabolism. We found that the expression of diacylglycerol O-acyltransferase1 (DGAT1) was significantly upregulated in the muscle of olive oil diet-fed mice. In addition, the olive oil diet-fed mice showed no metabolic impairment or differences in growth profiles compared to the controls. These results suggest that dietary olive oil intake affects muscle metabolism and muscle endurance by increasing energy accumulation.
橄榄油是一种具有多种生物活性的功能性食品。因此，我们期望它成为一种具有运动模拟作用的新型功能性食品，对骨骼肌产生影响。本研究旨在探讨橄榄油对小鼠耐力和肌肉代谢的影响。与大豆油饮食对照组相比，连续 8 周喂食 7%橄榄油饮食的小鼠在跑步机跑步耐力方面得到改善，并且比目鱼肌中的肌内三酰基甘油（IMTG）积累增加。橄榄油摄入对跑步耐力的提高与肌肉纤维类型无关。为了阐明 IMTG 水平升高的潜在机制，我们检查了与脂质代谢相关的基因的表达水平。我们发现，二酰基甘油 O-酰基转移酶 1（DGAT1）的表达在橄榄油饮食喂养的小鼠肌肉中显著上调。此外，与对照组相比，橄榄油饮食喂养的小鼠没有代谢损伤或生长曲线的差异。这些结果表明，饮食中橄榄油的摄入通过增加能量积累来影响肌肉代谢和肌肉耐力。
