视网膜静脉阻塞患者光学相干断层扫描血管造影的纵向变化
Longitudinal Changes on Optical Coherence Tomography Angiography in Retinal Vein Occlusion.
作者信息
Tripathy Swetapadma, Le Hong-Gam, Cicinelli Maria Vittoria, Gill Manjot K
机构信息
Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 N Michigan Avenue, Ste 440, Chicago, IL 60611, USA.
School of Medicine, Vita-Salute San Raffaele University, 20132 Milan, Italy.
出版信息
J Clin Med. 2021 Apr 1;10(7):1423. doi: 10.3390/jcm10071423.
BACKGROUND
To evaluate the longitudinal changes on optical coherence tomography angiography (OCTA) in retinal vein occlusion (RVO).
METHODS
Retrospective study of patients with RVO treated with intravitreal anti-vascular endothelial growth factors (VEGF) for macular edema. Foveal avascular zone (FAZ) area, vessel density (VD), vessel length density (VLD), and adjusted flow index (AFI) were calculated. The unaffected eye of each participant was used as a control.
RESULTS
Twelve RVO eyes were included, receiving 6 ± 3 anti-VEGF injections over a follow-up of 10.4 ± 3.1 months. Compared to fellow eyes, RVO eyes had lower VD and VLD at inclusion ( = 0.07 and = 0.04) and last visit ( = 0.002 and < 0.001). VD, AFI, and VLD did not change over time, while FAZ area increased in RVO eyes (+0.016 ± 0.024 mm, = 0.04). AFI correlated with duration of disease ( = 0.63, = 0.02). Visual acuity was inversely related to VD and VLD over the follow-up.
CONCLUSIONS
OCTA parameters remained stable with sustained anti-VEGF treatment in RVO, while changes in the FAZ area may suggest capillary remodeling after RVO.
背景
评估视网膜静脉阻塞（RVO）患者光学相干断层扫描血管造影（OCTA）的纵向变化。
方法
对接受玻璃体内抗血管内皮生长因子（VEGF）治疗黄斑水肿的RVO患者进行回顾性研究。计算黄斑无血管区（FAZ）面积、血管密度（VD）、血管长度密度（VLD）和校正血流指数（AFI）。将每位参与者的未受影响眼作为对照。
结果
纳入12只RVO眼，在10.4±3.1个月的随访期间接受了6±3次抗VEGF注射。与对侧眼相比，RVO眼在纳入时（P = 0.07和P = 0.04）及最后一次随访时（P = 0.002和P < 0.001）的VD和VLD较低。VD、AFI和VLD随时间未发生变化，而RVO眼的FAZ面积增加（+0.016±0.024 mm²，P = 0.04）。AFI与病程相关（r = 0.63，P = 0.02）。随访期间视力与VD和VLD呈负相关。
结论
在RVO患者中，持续抗VEGF治疗可使OCTA参数保持稳定，而FAZ面积的变化可能提示RVO后毛细血管重塑。
Zotero 插件