Dong Yan-Min, Zhu Hai-Yan, Liu Zhen-Hui, Fu Shu-Ying, Wang Ke, Du Li-Ping, Jin Xue-Min
Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China.
Int J Ophthalmol. 2022 Sep 18;15(9):1502-1510. doi: 10.18240/ijo.2022.09.14. eCollection 2022.
To describe the morphological characteristics of foveal avascular zone (FAZ) in normal Chinese adults with or without myopia by swept-source optical coherence tomography angiography (SS-OCTA) and analyze the possible associated factors.
Normal Chinese adults with or without myopia aged between 18 and 60y were recruited into the study. One eye in each individual was randomly selected for scanning using SS-OCTA. FAZ parameters, central retinal thickness (CRT) and central choroidal thickness (CCT) were then analyzed. Correlations between systemic and ocular variables and FAZ parameters were subsequently evaluated. The subgroup analysis based on refractive error was also carried out.
In total, 127 eyes out of 127 normal subjects were finally included in the study (mean age 29.5±8.22y, 61 males and 66 females). The pattern of FAZ was variable: round configuration in 28 eyes (22%), quadrilateral configuration in 23 eyes (18%), pentagonal configuration in 20 eyes (16%), oval configuration in 15 eyes (12%), triangular configuration in 6 eyes (5%) and irregular configuration in 35 eyes (28%). The mean area of FAZ was 0.37±0.12 mm. Females had a larger FAZ (0.41±0.11 mm 0.32±0.11 mm) compared with that of males (<0.01). All myopic individuals showed smaller FAZ area and perimeter compared with that of normal individuals (<0.01). There was no obvious correlation between age and FAZ. In the univariate regression analysis, both axial length (AL) and refractive error were significantly related to FAZ parameters. However, only CRT showed negative correlation with FAZ in the multivariate regression analysis.
The pattern of FAZ configuration in normal Chinese adults with or without myopia is highly variable. Establishing quantitative parameters of FAZ would not only provide details of macular pathophysiology but could possibly contribute as a biomarker in disease staging.
通过扫频光学相干断层扫描血管造影（SS-OCTA）描述正常中国成年人有或无近视时黄斑无血管区（FAZ）的形态特征，并分析可能的相关因素。
招募年龄在18至60岁之间的有或无近视的正常中国成年人参与研究。每位受试者随机选择一只眼睛使用SS-OCTA进行扫描。然后分析FAZ参数、中心视网膜厚度（CRT）和中心脉络膜厚度（CCT）。随后评估全身和眼部变量与FAZ参数之间的相关性。还基于屈光不正进行了亚组分析。
最终127名正常受试者的127只眼睛纳入研究（平均年龄29.5±8.22岁，男性61名，女性66名）。FAZ的形态多样：圆形28只眼（22%），四边形23只眼（18%），五边形20只眼（16%），椭圆形15只眼（12%），三角形6只眼（5%），不规则形35只眼（28%）。FAZ的平均面积为0.37±0.12平方毫米。女性的FAZ（0.41±0.11平方毫米）比男性的（0.32±0.11平方毫米）大（<0.01）。所有近视个体的FAZ面积和周长均比正常个体小（<0.01）。年龄与FAZ之间无明显相关性。在单因素回归分析中，眼轴长度（AL）和屈光不正均与FAZ参数显著相关。然而，在多因素回归分析中，只有CRT与FAZ呈负相关。
有或无近视的正常中国成年人中FAZ形态高度多样。建立FAZ的定量参数不仅能提供黄斑病理生理学的详细信息，还可能作为疾病分期的生物标志物。
